ENSG00000142515


Homo sapiens

Features
Gene ID: ENSG00000142515
  
Biological name :KLK3
  
Synonyms : kallikrein related peptidase 3 / KLK3 / P07288
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 50854915
Gene end: 50860764
  
Corresponding Affymetrix probe sets: 204582_s_at (Human Genome U133 Plus 2.0 Array)   204583_x_at (Human Genome U133 Plus 2.0 Array)   231629_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468912
Ensembl peptide - ENSP00000471827
Ensembl peptide - ENSP00000472213
Ensembl peptide - ENSP00000472411
Ensembl peptide - ENSP00000472907
Ensembl peptide - ENSP00000483513
Ensembl peptide - ENSP00000314151
Ensembl peptide - ENSP00000353829
Ensembl peptide - ENSP00000393628
Ensembl peptide - ENSP00000470523
Ensembl peptide - ENSP00000471155
Ensembl peptide - ENSP00000471648
NCBI entrez gene - 354     See in Manteia.
OMIM - 176820
RefSeq - NM_001030048
RefSeq - NM_001648
RefSeq - NM_001030047
RefSeq Peptide - NP_001025219
RefSeq Peptide - NP_001025218
RefSeq Peptide - NP_001639
swissprot - Q8WTQ8
swissprot - A0A0B4J1X3
swissprot - M0QX57
swissprot - M0QZF9
swissprot - M0R1F0
swissprot - M0R1Z7
swissprot - M0R294
swissprot - P07288
swissprot - Q546G3
swissprot - Q8NCW4
Ensembl - ENSG00000142515
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Klk1ENSMUSG00000063903Mus musculus
 Klk1b1ENSMUSG00000063133Mus musculus
 Klk1b3ENSMUSG00000066515Mus musculus
 Klk1b4ENSMUSG00000066513Mus musculus
 Klk1b5ENSMUSG00000066512Mus musculus
 Klk1b8ENSMUSG00000063089Mus musculus
 Klk1b9ENSMUSG00000059042Mus musculus
 P04071ENSMUSG00000038968Mus musculus
 P15946ENSMUSG00000044485Mus musculus
 P15948ENSMUSG00000060177Mus musculus
 P36369ENSMUSG00000053719Mus musculus
 Q61754ENSMUSG00000063713Mus musculus
 Q61759ENSMUSG00000066516Mus musculus
 Q9JM71ENSMUSG00000063177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLK2 / P20151 / kallikrein related peptidase 2ENSG0000016775177
KLK1 / P06870 / kallikrein 1ENSG0000016774861


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002778 antibacterial peptide production IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016525 negative regulation of angiogenesis NAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IMP


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000099769 IGFALS / P35858 / insulin like growth factor binding protein acid labile subunit  / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / reaction
 ENSG00000146674 IGFBP3 / P17936 / insulin like growth factor binding protein 3  / reaction
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / reaction






 

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