ENSG00000167748


Homo sapiens

Features
Gene ID: ENSG00000167748
  
Biological name :KLK1
  
Synonyms : kallikrein 1 / KLK1 / P06870
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 50819148
Gene end: 50823787
  
Corresponding Affymetrix probe sets: 216699_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472939
Ensembl peptide - ENSP00000301420
NCBI entrez gene - 3816     See in Manteia.
OMIM - 147910
RefSeq - XM_011526942
RefSeq - NM_002257
RefSeq Peptide - NP_002248
swissprot - A0A1R3UCD2
swissprot - P06870
swissprot - M0R318
Ensembl - ENSG00000167748
  
Related genetic diseases (OMIM): 615953 - [Kallikrein, decreased urinary activity of], 615953
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Klk1ENSMUSG00000063903Mus musculus
 Klk1b1ENSMUSG00000063133Mus musculus
 Klk1b3ENSMUSG00000066515Mus musculus
 Klk1b4ENSMUSG00000066513Mus musculus
 Klk1b5ENSMUSG00000066512Mus musculus
 Klk1b8ENSMUSG00000063089Mus musculus
 Klk1b9ENSMUSG00000059042Mus musculus
 P04071ENSMUSG00000038968Mus musculus
 P15946ENSMUSG00000044485Mus musculus
 P15948ENSMUSG00000060177Mus musculus
 P36369ENSMUSG00000053719Mus musculus
 Q61754ENSMUSG00000063713Mus musculus
 Q61759ENSMUSG00000066516Mus musculus
 Q9JM71ENSMUSG00000063177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLK2 / P20151 / kallikrein related peptidase 2ENSG0000016775165
KLK3 / P07288 / kallikrein related peptidase 3ENSG0000014251560


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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