ENSG00000167751


Homo sapiens

Features
Gene ID: ENSG00000167751
  
Biological name :KLK2
  
Synonyms : kallikrein related peptidase 2 / KLK2 / P20151
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 50861568
Gene end: 50880567
  
Corresponding Affymetrix probe sets: 1555545_at (Human Genome U133 Plus 2.0 Array)   209854_s_at (Human Genome U133 Plus 2.0 Array)   209855_s_at (Human Genome U133 Plus 2.0 Array)   210339_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471323
Ensembl peptide - ENSP00000471725
Ensembl peptide - ENSP00000472852
Ensembl peptide - ENSP00000472499
Ensembl peptide - ENSP00000472095
Ensembl peptide - ENSP00000313581
Ensembl peptide - ENSP00000350748
Ensembl peptide - ENSP00000375686
Ensembl peptide - ENSP00000469318
Ensembl peptide - ENSP00000469770
Ensembl peptide - ENSP00000471014
Ensembl peptide - ENSP00000471214
Ensembl peptide - ENSP00000471321
NCBI entrez gene - 3817     See in Manteia.
OMIM - 147960
RefSeq - NM_005551
RefSeq - NM_001002231
RefSeq - NM_001256080
RefSeq Peptide - NP_001002231
RefSeq Peptide - NP_001243009
RefSeq Peptide - NP_005542
swissprot - M0R1T3
swissprot - M0R2W5
swissprot - P20151
swissprot - A0A075B7A6
swissprot - Q6T774
swissprot - A0A024R4N3
swissprot - A0A024R4J4
swissprot - M0QXQ7
swissprot - M0R0M2
swissprot - M0R0M4
Ensembl - ENSG00000167751
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Klk1ENSMUSG00000063903Mus musculus
 Klk1b1ENSMUSG00000063133Mus musculus
 Klk1b3ENSMUSG00000066515Mus musculus
 Klk1b4ENSMUSG00000066513Mus musculus
 Klk1b5ENSMUSG00000066512Mus musculus
 Klk1b8ENSMUSG00000063089Mus musculus
 Klk1b9ENSMUSG00000059042Mus musculus
 P04071ENSMUSG00000038968Mus musculus
 P15946ENSMUSG00000044485Mus musculus
 P15948ENSMUSG00000060177Mus musculus
 P36369ENSMUSG00000053719Mus musculus
 Q61754ENSMUSG00000063713Mus musculus
 Q61759ENSMUSG00000066516Mus musculus
 Q9JM71ENSMUSG00000063177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLK3 / P07288 / kallikrein related peptidase 3ENSG0000014251577
KLK1 / P06870 / kallikrein 1ENSG0000016774865


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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