ENSG00000145431


Homo sapiens

Features
Gene ID: ENSG00000145431
  
Biological name :PDGFC
  
Synonyms : PDGFC / platelet derived growth factor C / Q9NRA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q32.1
Gene start: 156760454
Gene end: 156971394
  
Corresponding Affymetrix probe sets: 218718_at (Human Genome U133 Plus 2.0 Array)   222719_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274071
Ensembl peptide - ENSP00000410048
Ensembl peptide - ENSP00000422464
Ensembl peptide - ENSP00000424600
NCBI entrez gene - 56034     See in Manteia.
OMIM - 608452
RefSeq - XM_017008456
RefSeq - NM_016205
RefSeq - XM_011532124
RefSeq - XM_017008455
RefSeq Peptide - NP_057289
swissprot - Q9NRA1
swissprot - J3KN71
swissprot - H0Y9N2
Ensembl - ENSG00000145431
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfcENSDARG00000077588Danio rerio
 PDGFCENSGALG00000009378Gallus gallus
 PdgfcENSMUSG00000028019Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDGFD / Q9GZP0 / platelet derived growth factor DENSG0000017096243


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR000859  CUB domain
 IPR029034  Cystine-knot cytokine
 IPR029817  Platelet-derived growth factor C
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007596 blood coagulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IBA
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0045740 positive regulation of DNA replication IDA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104368 PLAT / P00750 / plasminogen activator, tissue type  / reaction
 ENSG00000122194 PLG / P00747 / plasminogen  / reaction
 ENSG00000145431 PDGFC / Q9NRA1 / platelet derived growth factor C  / complex






 

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