ENSGALG00000009378


Gallus gallus

Features
Gene ID: ENSGALG00000009378
  
Biological name :PDGFC
  
Synonyms : PDGFC / Platelet-derived growth factor C Platelet-derived growth factor C, latent form Platelet-derived growth factor C, receptor-binding form / Q9I946
  
Possible biological names infered from orthology : platelet derived growth factor C / platelet-derived growth factor, C polypeptide / Q8CI19 / Q9NRA1
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 21350186
Gene end: 21465992
  
Corresponding Affymetrix probe sets: Gga.1907.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015259
NCBI entrez gene - 395469     See in Manteia.
RefSeq - NM_204721
RefSeq Peptide - NP_990052
swissprot - Q9I946
Ensembl - ENSGALG00000009378
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfcENSDARG00000077588Danio rerio
 PDGFCENSG00000145431Homo sapiens
 PdgfcENSMUSG00000028019Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDGFD / platelet derived growth factor D / Q925I7* / Q9GZP0* / Mus musculus platelet-derived growth factor, D polypeptide (Pdgfd), transcript variant 2, mRNA.*ENSGALG0000001717944


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR000859  CUB domain
 IPR029034  Cystine-knot cytokine
 IPR029817  Platelet-derived growth factor C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007596 blood coagulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IBA
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IBA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by PDGF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004293 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSGALG00000003709 PLAT / plasminogen activator, tissue type / P00750* / P11214* / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B*  / reaction
 ENSGALG00000009378 PDGFC / Q9I946 / Platelet-derived growth factor C Platelet-derived growth factor C, latent form Platelet-derived growth factor C, receptor-binding form / Q9NRA1* / Q8CI19* / platelet derive...  / complex
 ENSGALG00000028886 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction






 

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