ENSGALG00000003709


Gallus gallus

Features
Gene ID: ENSGALG00000003709
  
Biological name :PLAT
  
Synonyms : plasminogen activator, tissue type / PLAT
  
Possible biological names infered from orthology : P00750 / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B
  
Species: Gallus gallus
  
Chr. number: 22
Strand: -1
Band:
Gene start: 2738388
Gene end: 2750600
  
Corresponding Affymetrix probe sets: Gga.11440.1.S1_at (Chicken Array)   Gga.11440.2.S1_at (Chicken Array)   GgaAffx.25955.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005876
NCBI entrez gene - 426791     See in Manteia.
RefSeq - XM_004947613
RefSeq - XM_015297381
RefSeq - XM_424404
swissprot - E1C209
Ensembl - ENSGALG00000003709
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 platENSDARG00000062707Danio rerio
 PLATENSG00000104368Homo sapiens
 PlatENSMUSG00000031538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HGFAC / HGF activator / Q04756* / Q9R098* / hepatocyte growth factor activator*ENSGALG0000001562330
LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*ENSGALG0000000429329
PLAU / plasminogen activator, urokinase / P00749* / P06869*ENSGALG0000000508629
HABP2 / hyaluronan-binding protein 2 preproprotein / Q14520* / hyaluronan binding protein 2* / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA.*ENSGALG0000000890528
LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*ENSGALG0000002888627
F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*ENSGALG0000000833224
MST1 / hepatocyte growth factor-like protein precursor / P26928* / macrophage stimulating 1* / macrophage stimulating 1 (hepatocyte growth factor-like)*ENSGALG0000000272221
HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*ENSGALG0000003397420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000083  Fibronectin, type I
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR013806  Kringle-like fold
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR026280  Tissue plasminogen activator
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0014909 smooth muscle cell migration IEA
 biological_processGO:0031639 plasminogen activation IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by PDGF
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004293 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / complex / reaction
 ENSGALG00000003709 PLAT / plasminogen activator, tissue type / P00750* / P11214* / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B*  / complex
 ENSGALG00000009378 PDGFC / Q9I946 / Platelet-derived growth factor C Platelet-derived growth factor C, latent form Platelet-derived growth factor C, receptor-binding form / Q9NRA1* / Q8CI19* / platelet derive...  / reaction
 ENSGALG00000017179 PDGFD / platelet derived growth factor D / Q925I7* / Q9GZP0* / Mus musculus platelet-derived growth factor, D polypeptide (Pdgfd), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000028886 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / complex / reaction






 

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