ENSG00000152670


Homo sapiens

Features
Gene ID: ENSG00000152670
  
Biological name :DDX4
  
Synonyms : DDX4 / DEAD-box helicase 4 / Q9NQI0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q11.2
Gene start: 55738017
Gene end: 55817157
  
Corresponding Affymetrix probe sets: 221630_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424112
Ensembl peptide - ENSP00000430431
Ensembl peptide - ENSP00000427522
Ensembl peptide - ENSP00000427167
Ensembl peptide - ENSP00000425359
Ensembl peptide - ENSP00000424838
Ensembl peptide - ENSP00000424779
Ensembl peptide - ENSP00000334167
Ensembl peptide - ENSP00000347087
Ensembl peptide - ENSP00000421960
Ensembl peptide - ENSP00000423102
Ensembl peptide - ENSP00000423123
NCBI entrez gene - 54514     See in Manteia.
OMIM - 605281
RefSeq - XM_011543497
RefSeq - NM_001142549
RefSeq - NM_001166533
RefSeq - NM_001166534
RefSeq - NM_024415
RefSeq - XM_011543495
RefSeq Peptide - NP_077726
RefSeq Peptide - NP_001136021
RefSeq Peptide - NP_001160005
RefSeq Peptide - NP_001160006
swissprot - D6RAT7
swissprot - D6RAF5
swissprot - D6RCM4
swissprot - H0YBW0
swissprot - H0Y960
swissprot - Q9NQI0
swissprot - D6RIB2
swissprot - D6RBL3
Ensembl - ENSG00000152670
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx4ENSDARG00000014373Danio rerio
 DDX4ENSGALG00000014713Gallus gallus
 Ddx4ENSMUSG00000021758Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX3Y / O15523 / DEAD-box helicase 3, Y-linkedENSG0000006704840
DDX3X / O00571 / DEAD-box helicase 3, X-linkedENSG0000021530139
DDX41 / Q9UJV9 / DEAD-box helicase 41ENSG0000018325826
DDX59 / Q5T1V6 / DEAD-box helicase 59ENSG0000011819723
DDX1 / Q92499 / DEAD-box helicase 1ENSG0000007978518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007140 male meiotic nuclear division ISS
 biological_processGO:0007141 male meiosis I ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0010529 negative regulation of transposition ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0034587 piRNA metabolic process ISS
 biological_processGO:0043046 DNA methylation involved in gamete generation ISS
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:1990511 piRNA biosynthetic process ISS
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043186 P granule IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IBA
 cellular_componentGO:0071546 pi-body ISS
 cellular_componentGO:0071547 piP-body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS


Pathways (from Reactome)
Pathway description
PIWI-interacting RNA (piRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr