ENSG00000067048


Homo sapiens

Features
Gene ID: ENSG00000067048
  
Biological name :DDX3Y
  
Synonyms : DDX3Y / DEAD-box helicase 3, Y-linked / O15523
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: Y
Strand: 1
Band: q11.221
Gene start: 12904108
Gene end: 12920478
  
Corresponding Affymetrix probe sets: 1570359_at (Human Genome U133 Plus 2.0 Array)   1570360_s_at (Human Genome U133 Plus 2.0 Array)   205000_at (Human Genome U133 Plus 2.0 Array)   205001_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353284
Ensembl peptide - ENSP00000400377
Ensembl peptide - ENSP00000398953
Ensembl peptide - ENSP00000336725
NCBI entrez gene - 8653     See in Manteia.
OMIM - 400010
RefSeq - NM_001122665
RefSeq - NM_001302552
RefSeq - NM_001324195
RefSeq - NM_004660
RefSeq Peptide - NP_001311124
RefSeq Peptide - NP_004651
RefSeq Peptide - NP_001116137
RefSeq Peptide - NP_001289481
swissprot - A0A024R9A4
swissprot - C9J8G5
swissprot - O15523
swissprot - C9J081
Ensembl - ENSG00000067048
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx3aENSDARG00000020573Danio rerio
 ddx3bENSDARG00000005774Danio rerio
 DDX3XENSGALG00000016231Gallus gallus
 Ddx3yENSMUSG00000069045Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX3X / O00571 / DEAD-box helicase 3, X-linkedENSG0000021530193
DDX4 / Q9NQI0 / DEAD-box helicase 4ENSG0000015267044
DDX41 / Q9UJV9 / DEAD-box helicase 41ENSG0000018325829
DDX59 / Q5T1V6 / DEAD-box helicase 59ENSG0000011819725
DDX1 / Q92499 / DEAD-box helicase 1ENSG0000007978521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006413 translational initiation IBA
 biological_processGO:0007059 chromosome segregation IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000027 Azoospermia 
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 HP:0000028 Cryptorchidism "Absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the testis." [HPO:curators]
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 HP:0000798 Oligospermia 
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 HP:0001450 Y-linked inheritance "A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome." [HPO:curators]
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 HP:0003251 Male infertility 
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 HP:0008734 Decreased testicular size 
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 HP:0011961 Non-obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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