ENSG00000183258


Homo sapiens

Features
Gene ID: ENSG00000183258
  
Biological name :DDX41
  
Synonyms : DDX41 / DEAD-box helicase 41 / Q9UJV9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.3
Gene start: 177511577
Gene end: 177517469
  
Corresponding Affymetrix probe sets: 217840_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426330
Ensembl peptide - ENSP00000487280
Ensembl peptide - ENSP00000486367
Ensembl peptide - ENSP00000427082
Ensembl peptide - ENSP00000330349
Ensembl peptide - ENSP00000421460
Ensembl peptide - ENSP00000422753
Ensembl peptide - ENSP00000425739
NCBI entrez gene - 51428     See in Manteia.
OMIM - 608170
RefSeq - NM_016222
RefSeq - NM_001321732
RefSeq - NM_001321830
RefSeq Peptide - NP_001308759
RefSeq Peptide - NP_001308661
RefSeq Peptide - NP_057306
swissprot - Q9UJV9
swissprot - D6RD33
swissprot - H0Y8L8
swissprot - H0YA06
swissprot - J3KNN5
swissprot - D6RGI7
Ensembl - ENSG00000183258
  
Related genetic diseases (OMIM): 616871 - {Myeloproliferative/lymphoproliferative neoplasms, familial (multiple types), susceptibility to}, 616871
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDX41ENSGALG00000042994Gallus gallus
 Ddx41ENSMUSG00000021494Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX3X / O00571 / DEAD-box helicase 3, X-linkedENSG0000021530132
DDX3Y / O15523 / DEAD-box helicase 3, Y-linkedENSG0000006704831
DDX4 / Q9NQI0 / DEAD-box helicase 4ENSG0000015267030
DDX59 / Q5T1V6 / DEAD-box helicase 59ENSG0000011819726
DDX1 / Q92499 / DEAD-box helicase 1ENSG0000007978519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0032479 regulation of type I interferon production TAS
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132109 P19474 / TRIM21 / tripartite motif containing 21  / complex / reaction






 

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