ENSG00000154269


Homo sapiens
activityENPP3domainextracellularprocessmembranebindingsomatomedinbendonucleasephosphodiesterasenucleotidepyrophosphatasealphasuperfamilymetabolicnucleicacidregionintegralcomponentdiphosphatasednarnanon-specifictypephosphatetransferasealkalinephosphatase-likebeta

Features
Gene ID: ENSG00000154269
  
Biological name :ENPP3
  
Synonyms : ectonucleotide pyrophosphatase/phosphodiesterase 3 / ENPP3 / O14638
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q23.2
Gene start: 131628442
Gene end: 131747418
  
Corresponding Affymetrix probe sets: 222938_x_at (Human Genome U133 Plus 2.0 Array)   232737_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000350964
Ensembl peptide - ENSP00000415589
Ensembl peptide - ENSP00000408642
Ensembl peptide - ENSP00000406261
Ensembl peptide - ENSP00000350265
NCBI entrez gene - 5169     See in Manteia.
OMIM - 602182
RefSeq - XM_017010932
RefSeq - NM_005021
RefSeq - XM_011535897
RefSeq Peptide - NP_005012
swissprot - E9PDB4
swissprot - O14638
swissprot - E7ETI7
swissprot - F8W6H5
Ensembl - ENSG00000154269
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENPP3ENSGALG00000037587Gallus gallus
 Enpp3ENSMUSG00000019989Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENPP1 / P22413 / ectonucleotide pyrophosphatase/phosphodiesterase 1ENSG0000019759452
ENPP2 / Q13822 / ectonucleotide pyrophosphatase/phosphodiesterase 2ENSG0000013696043
ENPP4 / Q9Y6X5 / ectonucleotide pyrophosphatase/phosphodiesterase 4ENSG0000000156117
ENPP5 / Q9UJA9 / ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)ENSG0000011279616
ENPP7 / Q6UWV6 / ectonucleotide pyrophosphatase/phosphodiesterase 7ENSG0000018215615
ENPP6 / Q6UWR7 / ectonucleotide pyrophosphatase/phosphodiesterase 6ENSG0000016430314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001212  Somatomedin B domain
 IPR001604  DNA/RNA non-specific endonuclease
 IPR002591  Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR020821  Extracellular Endonuclease, subunit A
 IPR036024  Somatomedin B-like domain superfamily


Gene Ontology (GO)
cellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processestablishment of localizationimmune responsenitrogen compound metabolic processbiosynthetic processcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabocellular metabolic processestablishment oestablishment of localizationimmune responseimmune responsenitrogen compounitrogen compound metabolic processbiosynthetic prbiosynthetic processcatabolic procecatabolic processprimary metabolprimary metabolic processsmall molecule small molecule metabolic processorganic substanorganic substance metabolic process
organic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compound bindingheterocyclic compound bindinghydrolase activityscavenger receptor activitycarbohydrate bindingpattern bindingion bindingorganic cyclic compoorganic cyclic compound bindingheterocyclic compounheterocyclic compound bindinghydrolase activityhydrolase activityscavenger receptor ascavenger receptor activitycarbohydrate bindingcarbohydrate bindingpattern bindingpattern bindingion bindingion binding
extracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regionextracellular regioncellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006796 phosphate-containing compound metabolic process IDA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009143 nucleoside triphosphate catabolic process IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004528 phosphodiesterase I activity TAS
 molecular_functionGO:0004551 nucleotide diphosphatase activity TAS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0035529 NADH pyrophosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047429 nucleoside-triphosphate diphosphatase activity IDA


Pathways (from Reactome)
Pathway description
Vitamin B5 (pantothenate) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154269 ENPP3 / O14638 / ectonucleotide pyrophosphatase/phosphodiesterase 3  / complex






 

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