ENSG00000162772


Homo sapiens
transcriptionATF3regulationrnapolymeraseiibindingdnaactivityproteinsequence-specificfactorresponsepromoterregulatoryregiondna-templateddomaindna-bindingcellendoplasmicreticulumunfoldederkproximaltranscriptionalap-basic-leucinezipperskn--like

Features
Gene ID: ENSG00000162772
  
Biological name :ATF3
  
Synonyms : activating transcription factor 3 / ATF3 / P18847
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.3
Gene start: 212565334
Gene end: 212620777
  
Corresponding Affymetrix probe sets: 1554420_at (Human Genome U133 Plus 2.0 Array)   1554980_a_at (Human Genome U133 Plus 2.0 Array)   202672_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480606
Ensembl peptide - ENSP00000432208
Ensembl peptide - ENSP00000483576
Ensembl peptide - ENSP00000336908
Ensembl peptide - ENSP00000344352
Ensembl peptide - ENSP00000355948
Ensembl peptide - ENSP00000355950
Ensembl peptide - ENSP00000355952
Ensembl peptide - ENSP00000355954
NCBI entrez gene - 467     See in Manteia.
OMIM - 603148
RefSeq - XM_011509579
RefSeq - NM_001030287
RefSeq - NM_001040619
RefSeq - NM_001206484
RefSeq - NM_001206486
RefSeq - NM_001206488
RefSeq - NM_001674
RefSeq - XM_005273146
RefSeq Peptide - NP_001025458
RefSeq Peptide - NP_001193413
RefSeq Peptide - NP_001193415
RefSeq Peptide - NP_001193417
RefSeq Peptide - NP_001665
RefSeq Peptide - NP_001035709
swissprot - Q5VTZ4
swissprot - A0A0A0MRJ2
swissprot - P18847
Ensembl - ENSG00000162772
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf3ENSDARG00000007823Danio rerio
 ATF3ENSGALG00000025887Gallus gallus
 Atf3ENSMUSG00000026628Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JDP2 / Q8WYK2 / Jun dimerization protein 2ENSG0000014004445


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029812  cAMP-dependent transcription factor ATF-3


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processsmall molecule metabolic processresponse to stresscell communicationresponse to chemicalcellular response to stimulusresponse to external stimulusanatomical structure developmentcellular developmental processcell deathnitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processcellular mcellular metabolic processprimary meprimary metabolic processorganic suorganic substance metabolic processsmall molesmall molecule metabolic processresponse tresponse to stresscell commucell communicationresponse tresponse to chemicalcellular rcellular response to stimulusresponse tresponse to external stimulusanatomicalanatomical structure developmentcellular dcellular developmental processcell deathcell death
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound bindingDNA-binding transcription faDNA-binding transcription factor activitytranscription coregulator actranscription coregulator activityprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006094 gluconeogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance TAS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway IMP
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:1990622 CHOP-ATF3 complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IGI
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
ATF4 activates genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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