ENSG00000168505


Homo sapiens

Features
Gene ID: ENSG00000168505
  
Biological name :GBX2
  
Synonyms : gastrulation brain homeobox 2 / GBX2 / P52951
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q37.2
Gene start: 236165236
Gene end: 236168369
  
Corresponding Affymetrix probe sets: 210560_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302251
Ensembl peptide - ENSP00000448747
NCBI entrez gene - 2637     See in Manteia.
OMIM - 601135
RefSeq - NM_001301687
RefSeq - NM_001485
RefSeq Peptide - NP_001288616
RefSeq Peptide - NP_001476
swissprot - P52951
swissprot - F8VY47
Ensembl - ENSG00000168505
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gbx2ENSDARG00000002933Danio rerio
 GBX2ENSGALG00000013342Gallus gallus
 Gbx2ENSMUSG00000034486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GBX1 / Q14549 / gastrulation brain homeobox 1ENSG0000016490050
MNX1 / P50219 / motor neuron and pancreas homeobox 1ENSG0000013067521
NKX1-1 / Q15270 / NK1 homeobox 1ENSG0000023560819
MEOX1 / P50221 / mesenchyme homeobox 1ENSG0000000510218
EVX1 / P49640 / even-skipped homeobox 1ENSG0000010603818
NKX1-2 / Q9UD57 / NK1 homeobox 2ENSG0000022954417
MEOX2 / P50222 / mesenchyme homeobox 2ENSG0000010651116
EVX2 / Q03828 / even-skipped homeobox 2ENSG0000017427916
VENTX / O95231 / VENT homeoboxENSG0000015165015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR031250  Homeobox protein GBX-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021555 midbrain-hindbrain boundary morphogenesis IEA
 biological_processGO:0021568 rhombomere 2 development IEA
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0021884 forebrain neuron development IEA
 biological_processGO:0021930 cerebellar granule cell precursor proliferation IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0030917 midbrain-hindbrain boundary development IEA
 biological_processGO:0035239 tube morphogenesis IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048483 autonomic nervous system development IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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