ENSG00000168925


Homo sapiens

Features
Gene ID: ENSG00000168925
  
Biological name :CTRB1
  
Synonyms : chymotrypsinogen B1 / CTRB1 / P17538
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q23.1
Gene start: 75219000
Gene end: 75226338
  
Corresponding Affymetrix probe sets: 205971_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000493978
Ensembl peptide - ENSP00000354294
Ensembl peptide - ENSP00000463301
NCBI entrez gene - 1504     See in Manteia.
OMIM - 118890
RefSeq - NM_001906
RefSeq Peptide - NP_001897
swissprot - J3QKZ2
swissprot - P17538
Ensembl - ENSG00000168925
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctrb1ENSDARG00000090428Danio rerio
 zgc:112160ENSDARG00000039730Danio rerio
 zgc:136461ENSDARG00000093844Danio rerio
 ENSGALG00000046107Gallus gallus
 CTRB2ENSGALG00000000038Gallus gallus
 Ctrb1ENSMUSG00000031957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTRB2 / Q6GPI1 / chymotrypsinogen B2ENSG0000016892896
CTRL / P40313 / chymotrypsin likeENSG0000014108654
CELA2A / P08217 / chymotrypsin like elastase family member 2AENSG0000014261541
CELA3B / P08861 / chymotrypsin like elastase family member 3BENSG0000021907341
CELA3A / P09093 / chymotrypsin like elastase family member 3AENSG0000014278940
CTRC / Q99895 / chymotrypsin CENSG0000016243839
CELA2B / P08218 / chymotrypsin like elastase family member 2BENSG0000021570439
OVCH2 / ovochymase 2 (gene/pseudogene)ENSG0000018337838
CELA1 / Q9UNI1 / chymotrypsin like elastase family member 1ENSG0000013961035
OVCH1 / Q7RTY7 / ovochymase 1ENSG0000018795034


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007586 digestion IEA
 biological_processGO:0009235 cobalamin metabolic process TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases
Cobalamin (Cbl, vitamin B12) transport and metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149968 MMP3 / P08254 / matrix metallopeptidase 3  / reaction
 ENSG00000168925 CTRB1 / P17538 / chymotrypsinogen B1  / complex






 

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