ENSG00000174516


Homo sapiens

Features
Gene ID: ENSG00000174516
  
Biological name :PELI3
  
Synonyms : PELI3 / pellino E3 ubiquitin protein ligase family member 3 / Q8N2H9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 66466327
Gene end: 66477337
  
Corresponding Affymetrix probe sets: 235431_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000322532
Ensembl peptide - ENSP00000484220
Ensembl peptide - ENSP00000436722
Ensembl peptide - ENSP00000436161
Ensembl peptide - ENSP00000434677
Ensembl peptide - ENSP00000434314
Ensembl peptide - ENSP00000432449
Ensembl peptide - ENSP00000309848
NCBI entrez gene - 246330     See in Manteia.
OMIM - 609827
RefSeq - XM_017017465
RefSeq - NM_001098510
RefSeq - NM_001243135
RefSeq - NM_001243136
RefSeq - NM_145065
RefSeq - XM_011544884
RefSeq Peptide - NP_001230065
RefSeq Peptide - NP_659502
RefSeq Peptide - NP_001091980
RefSeq Peptide - NP_001230064
swissprot - E9PQX6
swissprot - H0YEM6
swissprot - E9PI91
swissprot - A0A024R5I2
swissprot - A0A024R5B1
swissprot - Q8N2H9
swissprot - E9PR85
Ensembl - ENSG00000174516
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 peli3ENSDARG00000087452Danio rerio
 Peli3ENSMUSG00000024901Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2ENSG0000013994663
PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1ENSG0000019732963


Protein motifs (from Interpro)
Interpro ID Name
 IPR006800  Pellino family
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0008063 Toll signaling pathway IBA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070534 protein K63-linked ubiquitination IBA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000139946 PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2  / reaction
 ENSG00000174516 PELI3 / Q8N2H9 / pellino E3 ubiquitin protein ligase family member 3  / reaction
 ENSG00000197329 PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1  / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / reaction / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction






 

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