ENSMUSG00000024901


Mus musculus

Features
Gene ID: ENSMUSG00000024901
  
Biological name :Peli3
  
Synonyms : E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 / Peli3
  
Possible biological names infered from orthology : pellino E3 ubiquitin protein ligase family member 3 / Q8N2H9
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4930651
Gene end: 4943127
  
Corresponding Affymetrix probe sets: 10464896 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000025834
Ensembl peptide - ENSMUSP00000118173
Ensembl peptide - ENSMUSP00000113193
NCBI entrez gene - 240518     See in Manteia.
MGI - MGI:1924963
RefSeq - XM_006531745
RefSeq - XM_006531747
RefSeq - XM_006531746
RefSeq - NM_172835
RefSeq Peptide - NP_001334351
RefSeq Peptide - NP_766423
swissprot - D3Z6V8
swissprot - A0A0R4J057
swissprot - D3YYQ7
Ensembl - ENSMUSG00000024901
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 peli3ENSDARG00000087452Danio rerio
 PELI3ENSG00000174516Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Peli1 / Q8C669 / pellino 1 / Q96FA3* / pellino E3 ubiquitin protein ligase 1*ENSMUSG0000002013466
Peli2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8*ENSMUSG0000002184666


Protein motifs (from Interpro)
Interpro ID Name
 IPR006800  Pellino family
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008063 Toll signaling pathway IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011072 abnormal macrophage cytokine production "any anomaly in the appearance of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [GO:0010934]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024901 Peli3 / E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 / Q8N2H9* / pellino E3 ubiquitin protein ligase family member 3*  / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000021846 Peli2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8*  / reaction
 ENSMUSG00000020134 Peli1 / Q8C669 / pellino 1 / Q96FA3* / pellino E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr