ENSG00000175279


Homo sapiens

Features
Gene ID: ENSG00000175279
  
Biological name :CENPS
  
Synonyms : CENPS / centromere protein S / Q8N2Z9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.22
Gene start: 10430443
Gene end: 10442809
  
Corresponding Affymetrix probe sets: 213454_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000308583
Ensembl peptide - ENSP00000489524
Ensembl peptide - ENSP00000468629
NCBI entrez gene - 378708     See in Manteia.
OMIM - 609130
RefSeq - NM_199294
RefSeq Peptide - NP_954988
swissprot - A0A0U1RQL5
swissprot - K7ESB0
swissprot - Q8N2Z9
Ensembl - ENSG00000175279
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cenpsENSDARG00000070485Danio rerio
 CENPSENSGALG00000024481Gallus gallus
 CenpsENSMUSG00000073705Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CENPS-CORT / CENPS-CORT readthroughENSG0000025150369


Protein motifs (from Interpro)
Interpro ID Name
 IPR009072  Histone-fold
 IPR029003  CENP-S/Mhf1
 IPR033554  Centromere protein S


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IMP
 biological_processGO:0006281 DNA repair IDA
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0031297 replication fork processing IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination TAS
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051382 kinetochore assembly IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex IDA
 cellular_componentGO:0071821 FANCM-MHF complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Fanconi Anemia Pathway
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131944 FAAP24 / Q9BTP7 / Fanconi anemia core complex associated protein 24  / complex / reaction
 ENSG00000175279 CENPS / Q8N2Z9 / centromere protein S  / complex
 ENSG00000169689 CENPX / A8MT69 / centromere protein X  / complex
 ENSG00000187790 FANCM / Q8IYD8 / Fanconi anemia complementation group M  / complex / reaction






 

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