ENSG00000169689


Homo sapiens

Features
Gene ID: ENSG00000169689
  
Biological name :CENPX
  
Synonyms : A8MT69 / CENPX / centromere protein X
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 82018702
Gene end: 82024107
  
Corresponding Affymetrix probe sets: 209478_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464024
Ensembl peptide - ENSP00000463974
Ensembl peptide - ENSP00000464357
Ensembl peptide - ENSP00000302951
Ensembl peptide - ENSP00000376168
Ensembl peptide - ENSP00000462015
NCBI entrez gene - 201254     See in Manteia.
OMIM - 615128
RefSeq - XM_017024329
RefSeq - NM_001271006
RefSeq - NM_001271007
RefSeq - NM_144998
RefSeq - XM_005256339
RefSeq - XM_017024326
RefSeq - XM_017024327
RefSeq - XM_017024328
RefSeq Peptide - NP_001257935
RefSeq Peptide - NP_001317465
RefSeq Peptide - NP_659435
RefSeq Peptide - NP_001257936
swissprot - A8MT69
swissprot - J3QR01
swissprot - J3QR35
swissprot - J3QRS1
Ensembl - ENSG00000169689
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cenpxENSDARG00000089291Danio rerio
 CENPXENSGALG00000043607Gallus gallus
 CenpxENSMUSG00000025144Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018552  Centromere protein X


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0031297 replication fork processing IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination TAS
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051382 kinetochore assembly IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex IDA
 cellular_componentGO:0071821 FANCM-MHF complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Deposition of new CENPA-containing nucleosomes at the centromere
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175279 CENPS / Q8N2Z9 / centromere protein S  / complex
 ENSG00000131944 FAAP24 / Q9BTP7 / Fanconi anemia core complex associated protein 24  / complex / reaction
 ENSG00000169689 CENPX / A8MT69 / centromere protein X  / complex
 ENSG00000187790 FANCM / Q8IYD8 / Fanconi anemia complementation group M  / complex / reaction






 

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