ENSG00000185069


Homo sapiens
filamentKRT76intermediatekeratinproteintypeiidevelopmentkeratinizationconservedsiteheadcytoskeletonorganizationepidermispigmentationsebaceousglandcornificationnucleuscytosolextracellularexosomestructuralmoleculeactivityformationcornifiedenvelope

Features
Gene ID: ENSG00000185069
  
Biological name :KRT76
  
Synonyms : keratin 76 / KRT76 / Q01546
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 52768155
Gene end: 52777345
  
Corresponding Affymetrix probe sets: 207878_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000330101
NCBI entrez gene - 51350     See in Manteia.
OMIM - 616671
RefSeq - NM_015848
RefSeq Peptide - NP_056932
swissprot - Q01546
Ensembl - ENSG00000185069
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt4ENSDARG00000017624Danio rerio
 krt5ENSDARG00000058371Danio rerio
 krt8ENSDARG00000058358Danio rerio
 zgc:158846ENSDARG00000058462Danio rerio
 Krt76ENSMUSG00000075402Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KRT3 / P12035 / keratin 3ENSG0000018644276
KRT5 / P13647 / keratin 5ENSG0000018608158
KRT1 / P04264 / keratin 1ENSG0000016776857
KRT6C / P48668 / keratin 6CENSG0000017046557
KRT6B / P04259 / keratin 6BENSG0000018547957
KRT6A / P02538 / keratin 6AENSG0000020542057
KRT4 / P19013 / keratin 4ENSG0000017047755
KRT75 / O95678 / keratin 75ENSG0000017045454
KRT79 / Q5XKE5 / keratin 79ENSG0000018564052
KRT71 / Q3SY84 / keratin 71ENSG0000013964850
KRT8 / P05787 / keratin 8ENSG0000017042144
KRT7 / P08729 / keratin 7ENSG0000013548043


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
cellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationanatomical structure developmentcellular developmental processcell deathcellular component organizationcellular component organizationanatomical structure developmentanatomical structure developmentcellular developmental processcellular developmental processcell deathcell death
cellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellorganellesupramolecular complexextracellular regioncellcellorganelleorganellesupramolecular complexsupramolecular complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization NAS
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0031424 keratinization TAS
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0048733 sebaceous gland development IEA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005882 intermediate filament NAS
 cellular_componentGO:0045095 keratin filament IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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