ENSMUSG00000075402


Mus musculus

Features
Gene ID: ENSMUSG00000075402
  
Biological name :Krt76
  
Synonyms : Keratin, type II cytoskeletal 2 oral / Krt76 / Q3UV17
  
Possible biological names infered from orthology : keratin 76 / Q01546
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F2
Gene start: 101884351
Gene end: 101892920
  
Corresponding Affymetrix probe sets: 10432876 (MoGene1.0st)   1453279_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097754
NCBI entrez gene - 77055     See in Manteia.
MGI - MGI:1924305
RefSeq - NM_001033177
RefSeq Peptide - NP_001028349
swissprot - Q3UV17
Ensembl - ENSMUSG00000075402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt4ENSDARG00000017624Danio rerio
 krt5ENSDARG00000058371Danio rerio
 krt8ENSDARG00000058358Danio rerio
 zgc:158846ENSDARG00000058462Danio rerio
 KRT76ENSG00000185069Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt6a / P50446 / Keratin, type II cytoskeletal 6A / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000005835456
Krt5 / Q922U2 / keratin 5 / P13647*ENSMUSG0000006152756
Krt75 / Q8BGZ7 / Keratin, type II cytoskeletal 75 / O95678* / keratin 75*ENSMUSG0000002298655
Krt6b / keratin 6B / KRT6A* / KRT6C* / P02538* / P04259* / P48668* / keratin 6A* / keratin 6C*ENSMUSG0000002304155
Krt4 / P07744 / Keratin, type II cytoskeletal 4 / P19013* / keratin 4*ENSMUSG0000005966855
Krt90ENSMUSG0000004869951
Krt79 / Q8VED5 / Keratin, type II cytoskeletal 79 / Q5XKE5* / keratin 79*ENSMUSG0000006139751
Gm5414 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000006423248
Gm5478 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000009524148
Krt7 / Q9DCV7 / Keratin, type II cytoskeletal 7 / P08729* / keratin 7*ENSMUSG0000002303946
Krt8 / P11679 / Keratin, type II cytoskeletal 8 / P05787* / keratin 8*ENSMUSG0000004938244


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048733 sebaceous gland development IMP
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0045095 keratin filament IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0011276 increased tail pigmentation "visually detectable excess of pigment present on the tail surface" [MGI:csmith]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr