ENSMUSG00000022986


Mus musculus

Features
Gene ID: ENSMUSG00000022986
  
Biological name :Krt75
  
Synonyms : Keratin, type II cytoskeletal 75 / Krt75 / Q8BGZ7
  
Possible biological names infered from orthology : keratin 75 / O95678
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F2
Gene start: 101563345
Gene end: 101573904
  
Corresponding Affymetrix probe sets: 10432746 (MoGene1.0st)   1427378_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036246
NCBI entrez gene - 109052     See in Manteia.
MGI - MGI:1923500
RefSeq - NM_133357
RefSeq Peptide - NP_579935
swissprot - Q8BGZ7
Ensembl - ENSMUSG00000022986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt4ENSDARG00000017624Danio rerio
 krt5ENSDARG00000058371Danio rerio
 krt8ENSDARG00000058358Danio rerio
 zgc:158846ENSDARG00000058462Danio rerio
 KRT75ENSG00000170454Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt5 / Q922U2 / keratin 5 / P13647*ENSMUSG0000006152775
Krt6a / P50446 / Keratin, type II cytoskeletal 6A / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000005835473
Krt6b / keratin 6B / KRT6A* / KRT6C* / P02538* / P04259* / P48668* / keratin 6A* / keratin 6C*ENSMUSG0000002304172
Krt90ENSMUSG0000004869965
Gm5414 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000006423262
Krt76 / Q3UV17 / Keratin, type II cytoskeletal 2 oral / Q01546* / keratin 76*ENSMUSG0000007540259
Gm5478 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000009524159
Krt4 / P07744 / Keratin, type II cytoskeletal 4 / P19013* / keratin 4*ENSMUSG0000005966858
Krt79 / Q8VED5 / Keratin, type II cytoskeletal 79 / Q5XKE5* / keratin 79*ENSMUSG0000006139758
Krt7 / Q9DCV7 / Keratin, type II cytoskeletal 7 / P08729* / keratin 7*ENSMUSG0000002303952
Krt8 / P11679 / Keratin, type II cytoskeletal 8 / P05787* / keratin 8*ENSMUSG0000004938252


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005882 intermediate filament ISO
 cellular_componentGO:0045095 keratin filament IEA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CrygdL23/Crygd+
Genetic Background: involves: C57BL/6J

Allelic Composition: Krt6a/Krt6btm1Der/Krt6a+,Krt75tm1Der/Krt75+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Krt6a/Krt6btm1Der/Krt6a+,Krt75tm1Der/Krt75+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CrygdL23/Crygd+
Genetic Background: involves: C57BL/6J

Allelic Composition: Krt6a/Krt6btm1Der/Krt6a+,Krt75tm1Der/Krt75+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Krt75tm1Der/Krt75tm1Der
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt6a/Krt6btm1Der/Krt6a+,Krt75tm1Der/Krt75+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Krt75tm1Der/Krt75tm1Der
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Krt75tm1Der/Krt75tm1Der
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003812 abnormal hair medulla "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Krt6a/Krt6btm1Der/Krt6a+,Krt75tm1Der/Krt75+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Krt75tm1Der/Krt75tm1Der
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt6a/Krt6btm1Der/Krt6a+,Krt75tm1Der/Krt75+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Krt75tm1Der/Krt75tm1Der
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055937 Krt28 / A6BLY7 / Keratin, type I cytoskeletal 28 / Q7Z3Y7* / keratin 28*  / - / complex / reaction
 ENSMUSG00000017588 Krt27 / Q9Z320 / Keratin, type I cytoskeletal 27 / Q7Z3Y8* / keratin 27*  / - / complex / reaction
 ENSMUSG00000035831 Krt25 / Q8VCW2 / Keratin, type I cytoskeletal 25 / Q7Z3Z0* / keratin 25*  / - / complex / reaction
 ENSMUSG00000022986 Krt75 / Q8BGZ7 / Keratin, type II cytoskeletal 75 / O95678* / keratin 75*  / - / complex / reaction
 ENSMUSG00000056605 Krt72 / Q6IME9 / Keratin, type II cytoskeletal 72 / Q14CN4* / keratin 72*  / - / complex / reaction
 ENSMUSG00000063661 Krt73 / Q6NXH9 / Keratin, type II cytoskeletal 73 / Q86Y46* / keratin 73*  / - / complex / reaction






 

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