ENSMUSG00000035831


Mus musculus

Features
Gene ID: ENSMUSG00000035831
  
Biological name :Krt25
  
Synonyms : Keratin, type I cytoskeletal 25 / Krt25 / Q8VCW2
  
Possible biological names infered from orthology : keratin 25 / Q7Z3Z0
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 99315516
Gene end: 99322951
  
Corresponding Affymetrix probe sets: 10390798 (MoGene1.0st)   1418173_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048439
NCBI entrez gene - 70810     See in Manteia.
MGI - MGI:1918060
RefSeq - NM_133730
RefSeq - XM_017314757
RefSeq Peptide - NP_598491
swissprot - Q8VCW2
Ensembl - ENSMUSG00000035831
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyt1ENSDARG00000092947Danio rerio
 cyt1lENSDARG00000036832Danio rerio
 krt1-19dENSDARG00000023082Danio rerio
 krt15ENSDARG00000036840Danio rerio
 krt17ENSDARG00000094041Danio rerio
 krt91ENSDARG00000036830Danio rerio
 krt92ENSDARG00000036834Danio rerio
 krt93ENSDARG00000044976Danio rerio
 krt94ENSDARG00000044975Danio rerio
 krt95ENSDARG00000014356Danio rerio
 krt96ENSDARG00000095147Danio rerio
 krt97ENSDARG00000000212Danio rerio
 krtt1c19eENSDARG00000090268Danio rerio
 si:ch211-156l18.7ENSDARG00000022334Danio rerio
 KRT25ENSG00000204897Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt27 / Q9Z320 / Keratin, type I cytoskeletal 27 / Q7Z3Y8* / keratin 27*ENSMUSG0000001758881
Krt28 / A6BLY7 / Keratin, type I cytoskeletal 28 / Q7Z3Y7* / keratin 28*ENSMUSG0000005593773
Krt10 / keratin 10 / P13645*ENSMUSG0000001976153
Krt24 / A1L317 / Keratin, type I cytoskeletal 24 / Q2M2I5* / keratin 24*ENSMUSG0000002091353
Krt12 / keratin 12 / Q99456*ENSMUSG0000002091251
Krt16 / Q9Z2K1 / keratin 16 / P08779*ENSMUSG0000005379750
Krt14 / Q61781 / Keratin, type I cytoskeletal 14 ENSMUSG0000004554548
Krt13 / P08730 / Keratin, type I cytoskeletal 13 / P13646* / keratin 13*ENSMUSG0000004404147
Krt42 / Q6IFX2 / Keratin, type I cytoskeletal 42 ENSMUSG0000005365447
Krt15 / keratin 15 / P19012*ENSMUSG0000005414647
Krt17 / Q9QWL7 / Keratin, type I cytoskeletal 17 / Q04695* / keratin 17*ENSMUSG0000003555745
Krt19 / P19001 / Keratin, type I cytoskeletal 19 / P08727* / keratin 19*ENSMUSG0000002091144


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0042633 hair cycle IEA
 biological_processGO:0045109 intermediate filament organization IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005882 intermediate filament IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Fjx1tm1Awp/Fjx1+,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000399 increased curvature of guard hairs "greater bending arch of the guard hairs" [J:47620]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Krt25Re/Krt25Re
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

Allelic Composition: Krt25Rgsc573/Krt25Rgsc573
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Krt25M1Btlr/Krt25+
Genetic Background: C57BL/6J-Krt25M1Btlr

Allelic Composition: Krt25M2Btlr/Krt25+
Genetic Background: C57BL/6J-Krt25M2Btlr

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
Show

Allelic Composition: Fjx1tm1Awp/Fjx1+,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Fjx1tm1Awp/Fjx1+,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Krt25Re/Krt25Re
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt25Re/Krt25Re
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Krt25Re/Krt25Re
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0008899 plush coat "coat has a thick, velvet-like appearance" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt25M1Btlr/Krt25+
Genetic Background: C57BL/6J-Krt25M1Btlr

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0010685 abnormal hair follicle inner root sheath morphology "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]
Show

Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055937 Krt28 / A6BLY7 / Keratin, type I cytoskeletal 28 / Q7Z3Y7* / keratin 28*  / - / complex / reaction
 ENSMUSG00000017588 Krt27 / Q9Z320 / Keratin, type I cytoskeletal 27 / Q7Z3Y8* / keratin 27*  / - / complex / reaction
 ENSMUSG00000035831 Krt25 / Q8VCW2 / Keratin, type I cytoskeletal 25 / Q7Z3Z0* / keratin 25*  / - / complex / reaction
 ENSMUSG00000022986 Krt75 / Q8BGZ7 / Keratin, type II cytoskeletal 75 / O95678* / keratin 75*  / - / complex / reaction
 ENSMUSG00000056605 Krt72 / Q6IME9 / Keratin, type II cytoskeletal 72 / Q14CN4* / keratin 72*  / - / complex / reaction
 ENSMUSG00000063661 Krt73 / Q6NXH9 / Keratin, type II cytoskeletal 73 / Q86Y46* / keratin 73*  / - / complex / reaction






 

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