ENSMUSG00000017588


Mus musculus

Features
Gene ID: ENSMUSG00000017588
  
Biological name :Krt27
  
Synonyms : Keratin, type I cytoskeletal 27 / Krt27 / Q9Z320
  
Possible biological names infered from orthology : keratin 27 / Q7Z3Y8
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 99345565
Gene end: 99351104
  
Corresponding Affymetrix probe sets: 10390816 (MoGene1.0st)   1449378_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017732
NCBI entrez gene - 16675     See in Manteia.
MGI - MGI:1339999
RefSeq - NM_010666
RefSeq Peptide - NP_034796
swissprot - Q9Z320
Ensembl - ENSMUSG00000017588
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyt1ENSDARG00000092947Danio rerio
 cyt1lENSDARG00000036832Danio rerio
 krt1-19dENSDARG00000023082Danio rerio
 krt15ENSDARG00000036840Danio rerio
 krt17ENSDARG00000094041Danio rerio
 krt91ENSDARG00000036830Danio rerio
 krt92ENSDARG00000036834Danio rerio
 krt93ENSDARG00000044976Danio rerio
 krt94ENSDARG00000044975Danio rerio
 krt95ENSDARG00000014356Danio rerio
 krt96ENSDARG00000095147Danio rerio
 krt97ENSDARG00000000212Danio rerio
 krtt1c19eENSDARG00000090268Danio rerio
 si:ch211-156l18.7ENSDARG00000022334Danio rerio
 KRT27ENSG00000171446Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt25 / Q8VCW2 / Keratin, type I cytoskeletal 25 / Q7Z3Z0* / keratin 25*ENSMUSG0000003583181
Krt28 / A6BLY7 / Keratin, type I cytoskeletal 28 / Q7Z3Y7* / keratin 28*ENSMUSG0000005593775
Krt24 / A1L317 / Keratin, type I cytoskeletal 24 / Q2M2I5* / keratin 24*ENSMUSG0000002091355
Krt12 / keratin 12 / Q99456*ENSMUSG0000002091253
Krt10 / keratin 10 / P13645*ENSMUSG0000001976152
Krt14 / Q61781 / Keratin, type I cytoskeletal 14 ENSMUSG0000004554549
Krt42 / Q6IFX2 / Keratin, type I cytoskeletal 42 ENSMUSG0000005365449
Krt16 / Q9Z2K1 / keratin 16 / P08779*ENSMUSG0000005379749
Krt15 / keratin 15 / P19012*ENSMUSG0000005414648
Krt17 / Q9QWL7 / Keratin, type I cytoskeletal 17 / Q04695* / keratin 17*ENSMUSG0000003555747
Krt13 / P08730 / Keratin, type I cytoskeletal 13 / P13646* / keratin 13*ENSMUSG0000004404147
Krt19 / P19001 / Keratin, type I cytoskeletal 19 / P08727* / keratin 19*ENSMUSG0000002091144


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031069 hair follicle morphogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005882 intermediate filament IEA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000397 abnormal guard hair "anomalies of truncal hairs that contain two air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm2Xu/Trp53tm2Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm2Xu/Trp53tm2Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Polhtm1Fmh/Polhtm1Fmh
Genetic Background: involves: C57BL/6

Allelic Composition: Krt27Re-wc/Krt27Re-wc
Genetic Background: Not Specified

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
Show

Allelic Composition: Trp53tm2Xu/Trp53tm2Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Polhtm1Fmh/Polhtm1Fmh
Genetic Background: involves: C57BL/6

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Polhtm1Fmh/Polhtm1Fmh
Genetic Background: involves: C57BL/6

Allelic Composition: Krt27Re-wc/Krt27Re-wc
Genetic Background: Not Specified

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt27Re-wc/Krt27Re-wc
Genetic Background: Not Specified

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055937 Krt28 / A6BLY7 / Keratin, type I cytoskeletal 28 / Q7Z3Y7* / keratin 28*  / - / complex / reaction
 ENSMUSG00000017588 Krt27 / Q9Z320 / Keratin, type I cytoskeletal 27 / Q7Z3Y8* / keratin 27*  / - / complex / reaction
 ENSMUSG00000022986 Krt75 / Q8BGZ7 / Keratin, type II cytoskeletal 75 / O95678* / keratin 75*  / - / complex / reaction
 ENSMUSG00000056605 Krt72 / Q6IME9 / Keratin, type II cytoskeletal 72 / Q14CN4* / keratin 72*  / - / complex / reaction
 ENSMUSG00000063661 Krt73 / Q6NXH9 / Keratin, type II cytoskeletal 73 / Q86Y46* / keratin 73*  / - / complex / reaction
 ENSMUSG00000035831 Krt25 / Q8VCW2 / Keratin, type I cytoskeletal 25 / Q7Z3Z0* / keratin 25*  / - / complex / reaction






 

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