ENSMUSG00000049382


Mus musculus

Features
Gene ID: ENSMUSG00000049382
  
Biological name :Krt8
  
Synonyms : Keratin, type II cytoskeletal 8 / Krt8 / P11679
  
Possible biological names infered from orthology : keratin 8 / P05787
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F2
Gene start: 101996698
Gene end: 102004482
  
Corresponding Affymetrix probe sets: 10432918 (MoGene1.0st)   1420647_a_at (Mouse Genome 430 2.0 Array)   1423691_x_at (Mouse Genome 430 2.0 Array)   1435989_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023952
NCBI entrez gene - 16691     See in Manteia.
MGI - MGI:96705
RefSeq - NM_031170
RefSeq Peptide - NP_112447
swissprot - P11679
Ensembl - ENSMUSG00000049382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt4ENSDARG00000017624Danio rerio
 krt5ENSDARG00000058371Danio rerio
 krt8ENSDARG00000058358Danio rerio
 zgc:158846ENSDARG00000058462Danio rerio
 KRT8ENSG00000170421Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt5 / Q922U2 / keratin 5 / P13647*ENSMUSG0000006152760
Krt6a / P50446 / Keratin, type II cytoskeletal 6A / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000005835459
Krt75 / Q8BGZ7 / Keratin, type II cytoskeletal 75 / O95678* / keratin 75*ENSMUSG0000002298658
Krt6b / keratin 6B / KRT6A* / KRT6C* / P02538* / P04259* / P48668* / keratin 6A* / keratin 6C*ENSMUSG0000002304158
Krt90ENSMUSG0000004869958
Krt7 / Q9DCV7 / Keratin, type II cytoskeletal 7 / P08729* / keratin 7*ENSMUSG0000002303955
Krt4 / P07744 / Keratin, type II cytoskeletal 4 / P19013* / keratin 4*ENSMUSG0000005966853
Krt79 / Q8VED5 / Keratin, type II cytoskeletal 79 / Q5XKE5* / keratin 79*ENSMUSG0000006139753
Krt76 / Q3UV17 / Keratin, type II cytoskeletal 2 oral / Q01546* / keratin 76*ENSMUSG0000007540253
Gm5414 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000006423250
Gm5478 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000009524149


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000904 cell morphogenesis involved in differentiation TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0051599 response to hydrostatic pressure IEA
 biological_processGO:0051707 response to other organism IMP
 biological_processGO:0060706 cell differentiation involved in embryonic placenta development IGI
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:0097284 hepatocyte apoptotic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005882 intermediate filament ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016010 dystrophin-associated glycoprotein complex IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043034 costamere IEA
 cellular_componentGO:0045095 keratin filament IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001670 abnormal mineral absorption "anomalous ability of the body to take in any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub
Genetic Background: involves: 129S/SvEv

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006372 impaired placental function "reduction in the ability of the placenta to supply nutrients or remove waste" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0008959 abnormal spongiotrophoblast cell morphology "any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Krt19tm2Mmt/Krt19tm2Mmt,Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: FVB.129S2-Krt19tm2Mmt Krt8tm1Rgo

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Krt8tm1Rgo/Krt8tm1Rgo,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

Allelic Composition: Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Krt8tm1Rgo/Krt8tm1Rgo,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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