ENSMUSG00000059668


Mus musculus

Features
Gene ID: ENSMUSG00000059668
  
Biological name :Krt4
  
Synonyms : Keratin, type II cytoskeletal 4 / Krt4 / P07744
  
Possible biological names infered from orthology : keratin 4 / P19013
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F2
Gene start: 101918535
Gene end: 101924735
  
Corresponding Affymetrix probe sets: 10432886 (MoGene1.0st)   1418735_at (Mouse Genome 430 2.0 Array)   1438394_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023797
NCBI entrez gene - 16682     See in Manteia.
MGI - MGI:96701
RefSeq - NM_008475
RefSeq Peptide - NP_032501
swissprot - P07744
Ensembl - ENSMUSG00000059668
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt4ENSDARG00000017624Danio rerio
 krt5ENSDARG00000058371Danio rerio
 krt8ENSDARG00000058358Danio rerio
 zgc:158846ENSDARG00000058462Danio rerio
 KRT4ENSG00000170477Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt5 / Q922U2 / keratin 5 / P13647*ENSMUSG0000006152763
Krt76 / Q3UV17 / Keratin, type II cytoskeletal 2 oral / Q01546* / keratin 76*ENSMUSG0000007540262
Krt75 / Q8BGZ7 / Keratin, type II cytoskeletal 75 / O95678* / keratin 75*ENSMUSG0000002298661
Krt6a / P50446 / Keratin, type II cytoskeletal 6A / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000005835461
Krt6b / keratin 6B / KRT6A* / KRT6C* / P02538* / P04259* / P48668* / keratin 6A* / keratin 6C*ENSMUSG0000002304160
Krt90ENSMUSG0000004869958
Krt79 / Q8VED5 / Keratin, type II cytoskeletal 79 / Q5XKE5* / keratin 79*ENSMUSG0000006139758
Gm5478 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000009524154
Gm5414 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000006423252
Krt7 / Q9DCV7 / Keratin, type II cytoskeletal 7 / P08729* / keratin 7*ENSMUSG0000002303950
Krt8 / P11679 / Keratin, type II cytoskeletal 8 / P05787* / keratin 8*ENSMUSG0000004938250


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0009792 embryo development ending in birth or egg hatching TAS
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0045095 keratin filament ISO
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity TAS


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0000466 esophageal epithelium hyperplasia "increased cell number in the epithelial layer of the esophagus" [J:47225]
Show

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003745 abnormal mucosal lining of the mouth "anomalous structure or development of the mucus -secreting tissue that lines the oral cavity" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0003751 oral leukoplakia "white precancerous lesions of the mucous membranes of the oral cavity" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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