Manteia

ENSG00000211662

Homo sapiens

Features

Gene ID:	ENSG00000211662

Biological name :	IGLV3-21

Synonyms :	IGLV3-21 / immunoglobulin lambda variable 3-21 / P80748

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	22
Strand:	1
Band:	q11.22
Gene start:	22711689
Gene end:	22713203

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSP00000374843 swissprot - P80748 Ensembl - ENSG00000211662

See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name

Species

No match

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
IGLV3-12 / A0A075B6K2 / immunoglobulin lambda variable 3-12	ENSG00000211667	85
IGLV3-9 / A0A075B6K5 / immunoglobulin lambda variable 3-9 (gene/pseudogene)	ENSG00000211670	85
P01715 / IGLV3-1 / immunoglobulin lambda variable 3-1	ENSG00000211673	74
P01717 / IGLV3-25 / immunoglobulin lambda variable 3-25	ENSG00000211659	70
IGLV3-10 / A0A075B6K4 / immunoglobulin lambda variable 3-10	ENSG00000211669	68
IGLV3-16 / A0A075B6K0 / immunoglobulin lambda variable 3-16	ENSG00000211665	67
IGLV3-22 / A0A075B6J6 / immunoglobulin lambda variable 3-22 (gene/pseudogene)	ENSG00000211661	66
IGLV3-32 / immunoglobulin lambda variable 3-32 (non-functional)	ENSG00000211657	64
P01718 / IGLV3-27 / immunoglobulin lambda variable 3-27	ENSG00000211658	64
P01714 / IGLV3-19 / immunoglobulin lambda variable 3-19	ENSG00000211663	63
P01703 / IGLV1-40 / immunoglobulin lambda variable 1-40	ENSG00000211653	60
P01701 / IGLV1-51 / immunoglobulin lambda variable 1-51	ENSG00000211644	59
IGLV2-18 / A0A075B6J9 / immunoglobulin lambda variable 2-18	ENSG00000211664	59
P01721 / IGLV6-57 / immunoglobulin lambda variable 6-57	ENSG00000211640	57
IGLV1-50 / immunoglobulin lambda variable 1-50 (non-functional)	ENSG00000211645	57
P01706 / IGLV2-11 / immunoglobulin lambda variable 2-11	ENSG00000211668	57
P01704 / IGLV2-14 / immunoglobulin lambda variable 2-14	ENSG00000211666	56
P01705 / IGLV2-23 / immunoglobulin lambda variable 2-23	ENSG00000211660	55
P01709 / IGLV2-8 / immunoglobulin lambda variable 2-8	ENSG00000278196	55
P01700 / IGLV1-47 / immunoglobulin lambda variable 1-47	ENSG00000211648	54

Protein motifs (from Interpro)

Interpro ID

Name

No match

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006898	receptor-mediated endocytosis	TAS
biological_process	GO:0006955	immune response	NAS
biological_process	GO:0006956	complement activation	TAS
biological_process	GO:0006958	complement activation, classical pathway	TAS
biological_process	GO:0030449	regulation of complement activation	TAS
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0050776	regulation of immune response	TAS
biological_process	GO:0050900	leukocyte migration	TAS
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0072562	blood microparticle	HDA
molecular_function	GO:0003823	antigen binding	NAS
molecular_function	GO:0004252	serine-type endopeptidase activity	TAS

Pathways (from Reactome)

Pathway description

Initial triggering of complement

Classical antibody-mediated complement activation

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Cell surface interactions at the vascular wall

FCGR activation

Regulation of actin dynamics for phagocytic cup formation

Role of phospholipids in phagocytosis

Scavenging of heme from plasma

Fc epsilon receptor (FCERI) signaling

Role of LAT2/NTAL/LAB on calcium mobilization

FCERI mediated MAPK activation

FCERI mediated Ca+2 mobilization

FCERI mediated NF-kB activation

CD22 mediated BCR regulation

Regulation of Complement cascade

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr