ENSG00000255974


Homo sapiens

Features
Gene ID: ENSG00000255974
  
Biological name :CYP2A6
  
Synonyms : CYP2A6 / cytochrome P450 family 2 subfamily A member 6 / P11509
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 40843538
Gene end: 40850447
  
Corresponding Affymetrix probe sets: 1494_f_at (Human Genome U133 Plus 2.0 Array)   207244_x_at (Human Genome U133 Plus 2.0 Array)   211295_x_at (Human Genome U133 Plus 2.0 Array)   214320_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301141
Ensembl peptide - ENSP00000472905
NCBI entrez gene - 1548     See in Manteia.
OMIM - 122720
RefSeq - NM_000762
RefSeq Peptide - NP_000753
swissprot - P11509
swissprot - M0R2Z4
Ensembl - ENSG00000255974
  
Related genetic diseases (OMIM): 122700 - Coumarin resistance, 122700
  188890 - {Nicotine addiction, protection from}, 188890
  211980 - {Lung cancer, resistance to}, 211980
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2C9ENSDARG00000101423Danio rerio
 Cyp2a4ENSMUSG00000074254Mus musculus
 Cyp2a5ENSMUSG00000005547Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q16696 / CYP2A13 / cytochrome P450 family 2 subfamily A member 13ENSG0000019783894
CYP2A7 / P20853 / cytochrome P450 family 2 subfamily A member 7ENSG0000019807794
CYP2F1 / P24903 / cytochrome P450 family 2 subfamily F member 1ENSG0000019744652
P33261 / CYP2C19 / cytochrome P450 family 2 subfamily C member 19ENSG0000016584151
CYP2B6 / P20813 / cytochrome P450 family 2 subfamily B member 6ENSG0000019740851
P33260 / CYP2C18 / cytochrome P450 family 2 subfamily C member 18ENSG0000010824249
CYP2C9 / P11712 / cytochrome P450 family 2 subfamily C member 9ENSG0000013810949
CYP2C8 / P10632 / cytochrome P450 family 2 subfamily C member 8ENSG0000013811549
CYP2E1 / P05181 / cytochrome P450 family 2 subfamily E member 1ENSG0000013064947
AL583836.1ENSG0000027649030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008067  Cytochrome P450, E-class, group I, CYP2A-like
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008202 steroid metabolic process IMP
 biological_processGO:0009804 coumarin metabolic process TAS
 biological_processGO:0017144 drug metabolic process IMP
 biological_processGO:0019373 epoxygenase P450 pathway IBA
 biological_processGO:0042738 exogenous drug catabolic process IDA
 biological_processGO:0046226 coumarin catabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008389 coumarin 7-hydroxylase activity TAS
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IBA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Xenobiotics
CYP2E1 reactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
Show

 HP:0001871 Hematological abnormality 
Show

 HP:0001939 Metabolism abnormality 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr