ENSMUSG00000074254


Mus musculus

Features
Gene ID: ENSMUSG00000074254
  
Biological name :Cyp2a4
  
Synonyms : Cyp2a4 / Cytochrome P450 2A4 / P15392
  
Possible biological names infered from orthology : CYP2A13 / CYP2A6 / CYP2A7 / cytochrome P450 family 2 subfamily A member 13 / cytochrome P450 family 2 subfamily A member 6 / cytochrome P450 family 2 subfamily A member 7 / P11509 / P20853 / Q16696
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 26307169
Gene end: 26315088
  
Corresponding Affymetrix probe sets: 10551226 (MoGene1.0st)   1422230_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096254
NCBI entrez gene - 13086     See in Manteia.
MGI - MGI:88596
RefSeq - NM_009997
RefSeq Peptide - NP_034127
swissprot - P15392
Ensembl - ENSMUSG00000074254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2C9ENSDARG00000101423Danio rerio
 CYP2A6ENSG00000255974Homo sapiens
 CYP2A7ENSG00000198077Homo sapiens
 Q16696ENSG00000197838Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp2a5 / CYP2A6* / CYP2A7* / Q16696* / P20853* / P11509* / CYP2A13* / cytochrome P450 family 2 subfamily A member 7* / cytochrome P450 family 2 subfamily A member 6* / cytochrome P450 famil...ENSMUSG0000000554798
P56593 / Cyp2a12 / Cytochrome P450 2A12 ENSMUSG0000006040771
Cyp2a22 / cytochrome P450, family 2, subfamily a, polypeptide 22ENSMUSG0000009186770
Cyp2g1 / cytochrome P450, family 2, subfamily g, polypeptide 1ENSMUSG0000004968557
Cyp2b10 / CYP2B6* / P20813* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000003048353
Cyp2b23 / cytochrome P450, family 2, subfamily b, polypeptide 23 / CYP2B6* / P20813* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000004065053
P33267 / Cyp2f2 / Cytochrome P450 2F2 / CYP2F1* / P24903* / cytochrome P450 family 2 subfamily F member 1*ENSMUSG0000005297452
O55071 / Cyp2b19 / Cytochrome P450 2B19 / P20813* / CYP2B6* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000006670452
Cyp2c65 / cytochrome P450, family 2, subfamily c, polypeptide 65 / CYP2C9* / P33261* / P11712* / P10632* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P...ENSMUSG0000006723152
P56656 / Cyp2c39 / Cytochrome P450 2C39 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000002500351
P56655 / Cyp2c38 / Cytochrome P450 2C38 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000003280851
Cyp2b13 / cytochrome P450, family 2, subfamily b, polypeptide 13 / CYP2B6* / P20813* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000004058351
Cyp2c66 / cytochrome P450, family 2, subfamily c, polypeptide 66 / CYP2C9* / P33261* / P11712* / P10632* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P...ENSMUSG0000006722951
Q64458 / Cyp2c29 / Cytochrome P450 2C29 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000000305350
Cyp2c23 / cytochrome P450, family 2, subfamily c, polypeptide 23ENSMUSG0000002519750
Cyp2b9 / P12790 / Cytochrome P450 2B9 / P20813* / CYP2B6* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000004066050
P56654 / Cyp2c37 / Cytochrome P450 2C37 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000004224850
Q91X77 / Cyp2c50 / Cytochrome P450 2C50 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000005482750
Q9D816 / Cyp2c55 / Cytochrome P450 2C55 / P33260* / CYP2C18* / AL583836.1* / cytochrome P450 family 2 subfamily C member 18*ENSMUSG0000002500249
Q6XVG2 / Cyp2c54 / Cytochrome P450 2C54 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000006722549


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008067  Cytochrome P450, E-class, group I, CYP2A-like
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019373 epoxygenase P450 pathway IBA
 biological_processGO:0035634 response to stilbenoid IEP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005881 cytoplasmic microtubule ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008389 coumarin 7-hydroxylase activity ISO
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IBA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA


Pathways (from Reactome)
Pathway description
Fatty acids
Xenobiotics
CYP2E1 reactions
Aflatoxin activation and detoxification


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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