ENSGALG00000000667


Gallus gallus

Features
Gene ID: ENSGALG00000000667
  
Biological name :EDN2
  
Synonyms : EDN2 / endothelin 2
  
Possible biological names infered from orthology : P20800 / P22389
  
Species: Gallus gallus
  
Chr. number: 23
Strand: 1
Band:
Gene start: 953066
Gene end: 958386
  
Corresponding Affymetrix probe sets: Gga.8238.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000940
NCBI entrez gene - 419559     See in Manteia.
RefSeq - NM_001198655
RefSeq Peptide - NP_001185584
swissprot - E1C482
Ensembl - ENSGALG00000000667
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edn2ENSDARG00000070578Danio rerio
 EDN2ENSG00000127129Homo sapiens
 Edn2ENSMUSG00000028635Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EDN1 / endothelin 1 / P05305* / P22387* / Endothelin-1 Big endothelin-1*ENSGALG0000001273528
EDN3 / endothelin 3 / P14138* / P48299*ENSGALG0000004088022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001928  Endothelin-like toxin
 IPR015658  Endothelin-2
 IPR019764  Endothelin-like toxin, conserved site
 IPR020475  Endothelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IEA
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014824 artery smooth muscle contraction IEA
 biological_processGO:0014826 vein smooth muscle contraction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0048246 macrophage chemotaxis IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity IEA
 biological_processGO:0097009 energy homeostasis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031708 endothelin B receptor binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010013 EDNRA / endothelin receptor type A / P25101* / Q61614* / Endothelin-1 receptor *  / complex / reaction
 ENSGALG00000016912 EDNRB / endothelin receptor type B / P24530* / P48302*  / complex / reaction






 

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