ENSGALG00000003901


Gallus gallus
regulationP2RX4membraneiontransportsignalingactivitypxcalciumcardiacmuscleresponseatptransmembranecellintegralcomponentchannelpurinoreceptorbloodcalcium-mediatedpurinergicnucleotidereceptorpathwayendothelialcationplasmabindingpurinoceptor

Features
Gene ID: ENSGALG00000003901
  
Biological name :P2RX4
  
Synonyms : P2RX4 / P2X purinoceptor 4
  
Possible biological names infered from orthology : purinergic receptor P2X 4 / Q99571
  
Species: Gallus gallus
  
Chr. number: 15
Strand: 1
Band:
Gene start: 5471236
Gene end: 5477313
  
Corresponding Affymetrix probe sets: Gga.1369.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006191
Ensembl peptide - ENSGALP00000006190
NCBI entrez gene - 374166     See in Manteia.
RefSeq - NM_204291
RefSeq Peptide - NP_989622
swissprot - F1NC81
swissprot - E1C650
Ensembl - ENSGALG00000003901
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx4aENSDARG00000044752Danio rerio
 p2rx4bENSDARG00000042452Danio rerio
 P2RX4ENSG00000135124Homo sapiens
 P2rx4ENSMUSG00000029470Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2RX5 / Q93086* / P2RX5-TAX1BP3* / purinergic receptor P2X 5* / P2RX5-TAX1BP3 readthrough (NMD candidate)* / purinergic receptor P2X, ligand-gated ion channel, 5*ENSGALG0000000461354
P2RX1 / purinergic receptor P2X 1 / P51575* / P51576* / P2X purinoceptor 1 *ENSGALG0000000157352
P2RX3 / Gallus gallus purinergic receptor P2X 3 (P2RX3), mRNA. / Q3UR32* / P56373* / P2X purinoceptor 3 * / purinergic receptor P2X 3*ENSGALG0000004047943
P2RX6 / purinergic receptor P2X 6 / O15547*ENSGALG0000002690242
P2RX2 / purinergic receptor P2X 2 / Q8K3P1* / Q9UBL9* / P2X purinoceptor 2 *ENSGALG0000004464941
P2RX7 / purinergic receptor P2X 7 / Q99572* / Q9Z1M0* / P2X purinoceptor 7 *ENSGALG0000000386340


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003047  P2X4 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
establishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishment of localizationcell communicationcellular response to stimulusregulation of biological qualitysystem processcellular localizationresponse to external stimulusresponse to chemicalresponse to stresslocalization of cellmovement of cell or subcellular componenttissue migrationresponse to endogenous stimuluscell deathestablishmestablishment of localizationcell commucell communicationcellular rcellular response to stimulusregulationregulation of biological qualitysystem prosystem processcellular lcellular localizationresponse tresponse to external stimulusresponse tresponse to chemicalresponse tresponse to stresslocalizatilocalization of cellmovement omovement of cell or subcellular componenttissue migtissue migrationresponse tresponse to endogenous stimuluscell deathcell death
signaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling receptor activitytransmembrane transporter activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingprotein bindingsignaling recepsignaling receptor activitytransmembrane ttransmembrane transporter activityion bindingion bindingcarbohydrate decarbohydrate derivative bindingorganic cyclic organic cyclic compound bindingheterocyclic coheterocyclic compound bindingsmall molecule small molecule bindingdrug bindingdrug bindingprotein bindingprotein binding
cellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellmembraneorganellecell junctionsynapsecellcellmembranemembraneorganelleorganellecell junctioncell junctionsynapsesynapse
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0055119 relaxation of cardiac muscle IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071318 cellular response to ATP IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IBA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IBA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0099604 ligand-gated calcium channel activity IEA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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