ENSMUSG00000029470


Mus musculus

Features
Gene ID: ENSMUSG00000029470
  
Biological name :P2rx4
  
Synonyms : P2rx4 / purinergic receptor P2X 4
  
Possible biological names infered from orthology : Q99571
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 122707544
Gene end: 122729738
  
Corresponding Affymetrix probe sets: 10525439 (MoGene1.0st)   1425525_a_at (Mouse Genome 430 2.0 Array)   1441772_at (Mouse Genome 430 2.0 Array)   1446429_at (Mouse Genome 430 2.0 Array)   1452527_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117193
Ensembl peptide - ENSMUSP00000142849
Ensembl peptide - ENSMUSP00000118163
Ensembl peptide - ENSMUSP00000031429
Ensembl peptide - ENSMUSP00000080269
NCBI entrez gene - 18438     See in Manteia.
MGI - MGI:1338859
RefSeq - NM_001310720
RefSeq - XM_006530196
RefSeq - NM_011026
RefSeq - NM_001310718
RefSeq Peptide - NP_001297647
RefSeq Peptide - NP_001297649
RefSeq Peptide - NP_035156
swissprot - Q9Z257
swissprot - D3YYR5
swissprot - Q9Z256
swissprot - A0A0G2JEP2
swissprot - D3Z5U5
Ensembl - ENSMUSG00000029470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx4aENSDARG00000044752Danio rerio
 p2rx4bENSDARG00000042452Danio rerio
 P2RX4ENSGALG00000003901Gallus gallus
 P2RX4ENSG00000135124Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2rx5 / purinergic receptor P2X, ligand-gated ion channel, 5 / Q93086* / P2RX5-TAX1BP3* / purinergic receptor P2X 5* / P2RX5-TAX1BP3 readthrough (NMD candidate)*ENSMUSG0000000595051
P2rx1 / P51576 / P2X purinoceptor 1 / P51575* / purinergic receptor P2X 1*ENSMUSG0000002078751
P2rx7 / Q9Z1M0 / P2X purinoceptor 7 / Q99572* / purinergic receptor P2X 7*ENSMUSG0000002946846
P2rx2 / Q8K3P1 / P2X purinoceptor 2 / Q9UBL9* / purinergic receptor P2X 2*ENSMUSG0000002950345
P2rx6 / purinergic receptor P2X 6 / O15547*ENSMUSG0000002275844
P2rx3 / Q3UR32 / P2X purinoceptor 3 / P56373* / purinergic receptor P2X 3*ENSMUSG0000002707144


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003047  P2X4 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0019228 neuronal action potential IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0055119 relaxation of cardiac muscle IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071318 cellular response to ATP IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0099604 ligand-gated calcium channel activity IEA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zbtb33tm1.1Bird/Zbtb33tm1.1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zbtb33tm1.1Bird/Zbtb33tm1.1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighmtm1Che/Ighmtm1Che
Genetic Background: involves: 129 * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb33tm1.1Bird/Zbtb33tm1.1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb33tm1.1Bird/Zbtb33tm1.1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zbtb33tm1.1Bird/Zbtb33tm1.1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0011742 decreased urine nitrite level "lower than normal amount of nitrite (NO2-) in the urine; suggestive of impaired nitric oxide (NO) release" [MGI:anna]
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Allelic Composition: Zbtb33tm1.1Bird/Zbtb33tm1.1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012729 abnormal common carotid artery morphology "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]
Show

Allelic Composition: Zbtb33tm1.1Bird/Zbtb33tm1.1Bird
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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