ENSMUSG00000005950


Mus musculus

Features
Gene ID: ENSMUSG00000005950
  
Biological name :P2rx5
  
Synonyms : P2rx5 / purinergic receptor P2X, ligand-gated ion channel, 5
  
Possible biological names infered from orthology : P2RX5-TAX1BP3 / P2RX5-TAX1BP3 readthrough (NMD candidate) / purinergic receptor P2X 5 / Q93086
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B4
Gene start: 73160421
Gene end: 73172685
  
Corresponding Affymetrix probe sets: 10378319 (MoGene1.0st)   1449433_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121834
Ensembl peptide - ENSMUSP00000006104
Ensembl peptide - ENSMUSP00000118448
NCBI entrez gene - 94045     See in Manteia.
MGI - MGI:2137026
RefSeq - XM_006534566
RefSeq - NM_033321
RefSeq - XM_006534563
RefSeq - XM_006534564
RefSeq - XM_006534565
RefSeq Peptide - NP_201578
swissprot - B1AUD7
swissprot - B1AUD6
swissprot - Q3UYI1
Ensembl - ENSMUSG00000005950
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx5ENSDARG00000004455Danio rerio
 p2rx8ENSDARG00000024139Danio rerio
 P2RX5ENSGALG00000004613Gallus gallus
 P2RX5ENSG00000083454Homo sapiens
 P2RX5-TAX1BP3ENSG00000257950Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2rx4 / purinergic receptor P2X 4 / Q99571*ENSMUSG0000002947043
P2rx6 / purinergic receptor P2X 6 / O15547*ENSMUSG0000002275840
P2rx2 / Q8K3P1 / P2X purinoceptor 2 / Q9UBL9* / purinergic receptor P2X 2*ENSMUSG0000002950339
P2rx3 / Q3UR32 / P2X purinoceptor 3 / P56373* / purinergic receptor P2X 3*ENSMUSG0000002707138
P2rx1 / P51576 / P2X purinoceptor 1 / P51575* / purinergic receptor P2X 1*ENSMUSG0000002078736
P2rx7 / Q9Z1M0 / P2X purinoceptor 7 / Q99572* / purinergic receptor P2X 7*ENSMUSG0000002946835


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003048  P2X5 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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