ENSMUSG00000027071


Mus musculus

Features
Gene ID: ENSMUSG00000027071
  
Biological name :P2rx3
  
Synonyms : P2rx3 / P2X purinoceptor 3 / Q3UR32
  
Possible biological names infered from orthology : P56373 / purinergic receptor P2X 3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: D
Gene start: 84998583
Gene end: 85037462
  
Corresponding Affymetrix probe sets: 10484488 (MoGene1.0st)   1425093_at (Mouse Genome 430 2.0 Array)   1431321_at (Mouse Genome 430 2.0 Array)   1458396_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107243
Ensembl peptide - ENSMUSP00000028465
Ensembl peptide - ENSMUSP00000107240
NCBI entrez gene - 228139     See in Manteia.
MGI - MGI:1097160
RefSeq - XM_017317611
RefSeq - XM_006499209
RefSeq - XM_006499210
RefSeq - XM_011239452
RefSeq - XM_011239453
RefSeq - NM_145526
RefSeq Peptide - NP_663501
swissprot - A2AW04
swissprot - A2AW03
swissprot - Q3UR32
Ensembl - ENSMUSG00000027071
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx3aENSDARG00000010477Danio rerio
 p2rx3bENSDARG00000029718Danio rerio
 P2RX3ENSGALG00000040479Gallus gallus
 P2RX3ENSG00000109991Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2rx2 / Q8K3P1 / P2X purinoceptor 2 / Q9UBL9* / purinergic receptor P2X 2*ENSMUSG0000002950345
P2rx5 / purinergic receptor P2X, ligand-gated ion channel, 5 / Q93086* / P2RX5-TAX1BP3* / purinergic receptor P2X 5* / P2RX5-TAX1BP3 readthrough (NMD candidate)*ENSMUSG0000000595043
P2rx4 / purinergic receptor P2X 4 / Q99571*ENSMUSG0000002947043
P2rx1 / P51576 / P2X purinoceptor 1 / P51575* / purinergic receptor P2X 1*ENSMUSG0000002078741
P2rx7 / Q9Z1M0 / P2X purinoceptor 7 / Q99572* / purinergic receptor P2X 7*ENSMUSG0000002946838
P2rx6 / purinergic receptor P2X 6 / O15547*ENSMUSG0000002275837


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003046  P2X3 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IMP
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0009266 response to temperature stimulus IMP
 biological_processGO:0009408 response to heat IMP
 biological_processGO:0009409 response to cold IMP
 biological_processGO:0009612 response to mechanical stimulus IMP
 biological_processGO:0009743 response to carbohydrate IMP
 biological_processGO:0010033 response to organic substance IMP
 biological_processGO:0014832 urinary bladder smooth muscle contraction IMP
 biological_processGO:0019228 neuronal action potential IEA
 biological_processGO:0030432 peristalsis IMP
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0048266 behavioral response to pain IMP
 biological_processGO:0050909 sensory perception of taste IGI
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0061368 behavioral response to formalin induced pain IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1904058 positive regulation of sensory perception of pain IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Grhl3ct/Grhl3ct-J
Genetic Background: Not Specified

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist2tm1(cre)Dor/Twist2+,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Twist2tm1(cre)Dor/Twist2+,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002735 abnormal chemical nociception "abnormal capability to sense pain elicited by chemical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Twist2tm1(cre)Dor/Twist2+,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003438 abnormal carotid body physiology "any functional change in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Twist2tm1(cre)Dor/Twist2+,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005576 decreased pulmonary ventilation "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grhl3ct/Grhl3ct-J
Genetic Background: Not Specified

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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