ENSGALG00000003863


Gallus gallus

Features
Gene ID: ENSGALG00000003863
  
Biological name :P2RX7
  
Synonyms : P2RX7 / purinergic receptor P2X 7
  
Possible biological names infered from orthology : P2X purinoceptor 7 / Q99572 / Q9Z1M0
  
Species: Gallus gallus
  
Chr. number: 15
Strand: 1
Band:
Gene start: 5458325
Gene end: 5469803
  
Corresponding Affymetrix probe sets: GgaAffx.26037.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006141
NCBI entrez gene - 771952     See in Manteia.
RefSeq - XM_001235162
swissprot - E1C6P3
Ensembl - ENSGALG00000003863
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx7ENSDARG00000042440Danio rerio
 P2RX7ENSG00000089041Homo sapiens
 P2rx7ENSMUSG00000029468Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2RX4 / P2X purinoceptor 4 / Q99571* / purinergic receptor P2X 4*ENSGALG0000000390127
P2RX5 / Q93086* / P2RX5-TAX1BP3* / purinergic receptor P2X 5* / P2RX5-TAX1BP3 readthrough (NMD candidate)* / purinergic receptor P2X, ligand-gated ion channel, 5*ENSGALG0000000461326
P2RX1 / purinergic receptor P2X 1 / P51575* / P51576* / P2X purinoceptor 1 *ENSGALG0000000157325
P2RX3 / Gallus gallus purinergic receptor P2X 3 (P2RX3), mRNA. / Q3UR32* / P56373* / P2X purinoceptor 3 * / purinergic receptor P2X 3*ENSGALG0000004047923
P2RX6 / purinergic receptor P2X 6 / O15547*ENSGALG0000002690221
P2RX2 / purinergic receptor P2X 2 / Q8K3P1* / Q9UBL9* / P2X purinoceptor 2 *ENSGALG0000004464921


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003050  P2X7 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001845 phagolysosome assembly IEA
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0006649 phospholipid transfer to membrane IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006884 cell volume homeostasis IEA
 biological_processGO:0006900 vesicle budding from membrane IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007009 plasma membrane organization IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010467 gene expression IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0014054 positive regulation of gamma-aminobutyric acid secretion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0017121 phospholipid scrambling IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0032308 positive regulation of prostaglandin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032963 collagen metabolic process IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0034767 positive regulation of ion transmembrane transport IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043132 NAD transport IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045332 phospholipid translocation IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045779 negative regulation of bone resorption IEA
 biological_processGO:0045794 negative regulation of cell volume IEA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0046513 ceramide biosynthetic process IEA
 biological_processGO:0046931 pore complex assembly IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050717 positive regulation of interleukin-1 alpha secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0070230 positive regulation of lymphocyte apoptotic process IEA
 biological_processGO:0071359 cellular response to dsRNA IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1904172 positive regulation of bleb assembly IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IBA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IBA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015267 channel activity IEA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003863 P2RX7 / purinergic receptor P2X 7 / Q99572* / Q9Z1M0* / P2X purinoceptor 7 *  / complex
 ENSGALG00000039751 PANX1 / pannexin 1 / Q96RD7* / Q9JIP4*  / complex






 

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