ENSGALG00000004960


Gallus gallus

Features
Gene ID: ENSGALG00000004960
  
Biological name :FBN1
  
Synonyms : FBN1 / fibrillin 1
  
Possible biological names infered from orthology : Fibrillin-1 Asprosin / P35555 / Q61554
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 10168070
Gene end: 10300782
  
Corresponding Affymetrix probe sets: Gga.2888.1.S1_at (Chicken Array)   Gga.2888.2.S1_at (Chicken Array)   Gga.8491.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007941
NCBI entrez gene - 373992     See in Manteia.
RefSeq - XM_015291934
RefSeq - XM_015291935
swissprot - F1NII7
Ensembl - ENSGALG00000004960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbn2aENSDARG00000051896Danio rerio
 FBN1ENSG00000166147Homo sapiens
 Fbn1ENSMUSG00000027204Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000003762565
FBN2 / fibrillin 2 / P35556* / Q61555* / Fibrillin-2 Fibrillin-2 C-terminal peptide*ENSGALG0000001468661
LTBP2 / latent transforming growth factor beta binding protein 2 / Q14767*ENSGALG0000001025816
LTBP1 / latent-transforming growth factor beta-binding protein 1 precursor / Q14766* / Q8CG19* / latent transforming growth factor beta binding protein 1*ENSGALG0000001044814
FBLN1 / fibulin-1 precursor / P23142* / Q08879* / fibulin 1* / Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA.*ENSGALG000000142337
ENSGALG000000051204
FBLN5 / fibulin 5 / Q9UBX5* / Q9WVH9*ENSGALG000000107474
ENSGALG000000377114
EFEMP1 / EGF containing fibulin extracellular matrix protein 1 / Q12805* / Q8BPB5* / EGF-containing fibulin-like extracellular matrix protein 1 *ENSGALG000000379014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002557  Chitin binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR017878  TB domain
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0006030 chitin metabolic process IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0035582 sequestering of BMP in extracellular matrix IEA
 biological_processGO:0035583 sequestering of TGFbeta in extracellular matrix IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0048048 embryonic eye morphogenesis IEA
 biological_processGO:0048050 post-embryonic eye morphogenesis IEA
 biological_processGO:0090287 regulation of cellular response to growth factor stimulus IBA
 biological_processGO:2001205 negative regulation of osteoclast development IEA
 cellular_componentGO:0001527 microfibril IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008061 chitin binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Elastic fibre formation
Molecules associated with elastic fibres
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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