ENSGALG00000008257


Gallus gallus

Features
Gene ID: ENSGALG00000008257
  
Biological name :MERTK
  
Synonyms : MERTK / tyrosine-protein kinase Mer precursor
  
Possible biological names infered from orthology : MER proto-oncogene, tyrosine kinase / Q12866 / Q60805 / Tyrosine-protein kinase Mer
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 3200895
Gene end: 3221901
  
Corresponding Affymetrix probe sets: Gga.2893.1.S1_a_at (Chicken Array)   GgaAffx.11560.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013423
Ensembl peptide - ENSGALP00000063501
Ensembl peptide - ENSGALP00000056697
Ensembl peptide - ENSGALP00000054730
Ensembl peptide - ENSGALP00000054188
NCBI entrez gene - 395836     See in Manteia.
RefSeq - NM_204988
RefSeq - XM_015283347
RefSeq - XM_015283348
RefSeq Peptide - NP_990319
swissprot - A0A1L1RXD9
swissprot - F1P3V0
swissprot - A0A1D5PUU0
swissprot - A0A1D5PPD1
swissprot - A0A1D5PMV1
Ensembl - ENSGALG00000008257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mertkaENSDARG00000074695Danio rerio
 MERTKENSG00000153208Homo sapiens
 MertkENSMUSG00000014361Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TYRO3 / tyrosine-protein kinase receptor TYRO3 precursor / Q06418* / P55144* / TYRO3 protein tyrosine kinase* / TYRO3 protein tyrosine kinase 3*ENSGALG0000000863134
TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*ENSGALG0000000184022
MST1R / macrophage-stimulating protein receptor precursor / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSGALG0000000310322
MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*ENSGALG0000003688321
TIE1 / tyrosine kinase with immunoglobulin like and EGF like domains 1 / P35590* / Q06806*ENSGALG0000000995719
RYK / receptor-like tyrosine kinase / Q01887* / Tyrosine-protein kinase RYK *ENSGALG0000000648817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IEA
 biological_processGO:0001818 negative regulation of cytokine production IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0032940 secretion by cell IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0051250 negative regulation of lymphocyte activation IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060068 vagina development IEA
 biological_processGO:0097350 neutrophil clearance IEA
 biological_processGO:2000107 negative regulation of leukocyte apoptotic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016028 rhabdomere IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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