ENSGALG00000010379


Gallus gallus
regulationSNCAbindingprocesssynapticactivityresponseionmetabolicapoptoticmembraneproteinreceptorsecretiontransmissioninvolveddopaminecellactivationcysteine-typeendopeptidaseorganizationbiosyntheticneuronneuronaluptakeneurotransmitteracidphospholipidmitochondrialiron

Features
Gene ID: ENSGALG00000010379
  
Biological name :SNCA
  
Synonyms : SNCA / synuclein alpha
  
Possible biological names infered from orthology : Alpha-synuclein / O55042 / P37840
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 35648927
Gene end: 35715824
  
Corresponding Affymetrix probe sets: Gga.2726.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049110
Ensembl peptide - ENSGALP00000016889
NCBI entrez gene - 395393     See in Manteia.
RefSeq - XM_015276121
RefSeq - NM_204673
RefSeq Peptide - NP_990004
swissprot - Q9I9H1
swissprot - A0A1D5P8R1
Ensembl - ENSGALG00000010379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SNCAENSG00000145335Homo sapiens
 SncaENSMUSG00000025889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SNCB / synuclein beta / Q16143* / Q91ZZ3* / Beta-synuclein *ENSGALG0000002154252
SNCG / synuclein gamma / O76070* / Q9Z0F7*ENSGALG0000000201548


Protein motifs (from Interpro)
Interpro ID Name
 IPR001058  Synuclein
 IPR002460  Alpha-synuclein


Gene Ontology (GO)
cell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcell activationcellular metabolic processorganic substance metabolic processcell communicationestablishment of localizationregulation of biological qualitycellular localizationprimary metabolic processsmall molecule metabolic processnitrogen compound metabolic processregulation of molecular functioncell deathcellular component organizationlocomotory behavioradult behaviorresponse to chemicalcellular response to stimuluscellular component biogenesismicrotubule-based processresponse to external stimulusresponse to biotic stimulusresponse to stressimmune responsebiosynthetic processoxidation-reduction processsystem processcatabolic processprocess utilizing autophagic mechanismanatomical structure developmentcellcell activationcellcellular metabolic processorgaorganic substance metabolic processcellcell communicationestaestablishment of localizationreguregulation of biological qualitycellcellular localizationprimprimary metabolic processsmalsmall molecule metabolic processnitrnitrogen compound metabolic processreguregulation of molecular functioncellcell deathcellcellular component organizationlocolocomotory behavioraduladult behaviorrespresponse to chemicalcellcellular response to stimuluscellcellular component biogenesismicrmicrotubule-based processrespresponse to external stimulusrespresponse to biotic stimulusrespresponse to stressimmuimmune responsebiosbiosynthetic processoxidoxidation-reduction processsystsystem processcatacatabolic processprocprocess utilizing autophagic mechanismanatanatomical structure development
ion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindinglipid bindingoxidoreductase activityprotein bindingenzyme regulator activityfatty acid derivative bindingsmall molecule bindingprotein-containing complex bindingion bindingion bindinglipid bindinglipid bindingoxidoreductase acoxidoreductase activityprotein bindingprotein bindingenzyme regulator enzyme regulator activityfatty acid derivafatty acid derivative bindingsmall molecule bismall molecule bindingprotein-containinprotein-containing complex binding
extracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regioncellorganellemembranesynapsesupramolecular complexextracellular regionextracellular regioncellcellorganelleorganellemembranemembranesynapsesynapsesupramolecular complexsupramolecular complex
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0001956 positive regulation of neurotransmitter secretion IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006638 neutral lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007006 mitochondrial membrane organization IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0010040 response to iron(II) ion IEA
 biological_processGO:0010517 regulation of phospholipase activity IEA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0014048 regulation of glutamate secretion IEA
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0031115 negative regulation of microtubule polymerization IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032410 negative regulation of transporter activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032769 negative regulation of monooxygenase activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035067 negative regulation of histone acetylation IEA
 biological_processGO:0040012 regulation of locomotion IEA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0042417 dopamine metabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042775 mitochondrial ATP synthesis coupled electron transport IEA
 biological_processGO:0043030 regulation of macrophage activation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0045920 negative regulation of exocytosis IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IEA
 biological_processGO:0048489 synaptic vesicle transport IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050806 positive regulation of synaptic transmission IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050812 regulation of acyl-CoA biosynthetic process IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051585 negative regulation of dopamine uptake involved in synaptic transmission IEA
 biological_processGO:0051612 negative regulation of serotonin uptake IEA
 biological_processGO:0051622 negative regulation of norepinephrine uptake IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 biological_processGO:0061024 membrane organization IEA
 biological_processGO:0070495 negative regulation of thrombin-activated receptor signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1903284 positive regulation of glutathione peroxidase activity IEA
 biological_processGO:1903285 positive regulation of hydrogen peroxide catabolic process IEA
 biological_processGO:1904715 negative regulation of chaperone-mediated autophagy IEA
 biological_processGO:1905606 regulation of presynapse assembly IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031092 platelet alpha granule membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0099512 supramolecular fiber IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008198 ferrous iron binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0050544 arachidonic acid binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA
 molecular_functionGO:1903136 cuprous ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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