ENSMUSG00000025889


Mus musculus

Features
Gene ID: ENSMUSG00000025889
  
Biological name :Snca
  
Synonyms : Alpha-synuclein / O55042 / Snca
  
Possible biological names infered from orthology : P37840 / synuclein alpha
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 60731575
Gene end: 60829855
  
Corresponding Affymetrix probe sets: 10545086 (MoGene1.0st)   1418493_a_at (Mouse Genome 430 2.0 Array)   1431022_at (Mouse Genome 430 2.0 Array)   1436853_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109907
Ensembl peptide - ENSMUSP00000126067
NCBI entrez gene - 20617     See in Manteia.
MGI - MGI:1277151
RefSeq - NM_001042451
RefSeq - NM_009221
RefSeq Peptide - NP_001035916
RefSeq Peptide - NP_033247
swissprot - O55042
Ensembl - ENSMUSG00000025889
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SNCAENSGALG00000010379Gallus gallus
 SNCAENSG00000145335Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sncb / Q91ZZ3 / Beta-synuclein / Q16143* / synuclein beta*ENSMUSG0000003489161
Sncg / Q9Z0F7 / synuclein, gamma / O76070*ENSMUSG0000002306451


Protein motifs (from Interpro)
Interpro ID Name
 IPR001058  Synuclein
 IPR002460  Alpha-synuclein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IMP
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001956 positive regulation of neurotransmitter secretion IDA
 biological_processGO:0001963 synaptic transmission, dopaminergic IMP
 biological_processGO:0006631 fatty acid metabolic process IMP
 biological_processGO:0006638 neutral lipid metabolic process IMP
 biological_processGO:0006644 phospholipid metabolic process IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007006 mitochondrial membrane organization IMP
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0007568 aging IEA
 biological_processGO:0008344 adult locomotory behavior IGI
 biological_processGO:0010040 response to iron(II) ion IEA
 biological_processGO:0010517 regulation of phospholipase activity IEA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0014048 regulation of glutamate secretion IMP
 biological_processGO:0014059 regulation of dopamine secretion TAS
 biological_processGO:0031115 negative regulation of microtubule polymerization IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032410 negative regulation of transporter activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032769 negative regulation of monooxygenase activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0035067 negative regulation of histone acetylation IEA
 biological_processGO:0040012 regulation of locomotion IMP
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042416 dopamine biosynthetic process IMP
 biological_processGO:0042417 dopamine metabolic process IGI
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0042775 mitochondrial ATP synthesis coupled electron transport IMP
 biological_processGO:0043030 regulation of macrophage activation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0045920 negative regulation of exocytosis IEA
 biological_processGO:0045963 negative regulation of dopamine metabolic process IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IMP
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0048488 synaptic vesicle endocytosis IMP
 biological_processGO:0048489 synaptic vesicle transport IMP
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050806 positive regulation of synaptic transmission IMP
 biological_processGO:0050808 synapse organization IGI
 biological_processGO:0050812 regulation of acyl-CoA biosynthetic process IMP
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051585 negative regulation of dopamine uptake involved in synaptic transmission IEA
 biological_processGO:0051612 negative regulation of serotonin uptake IEA
 biological_processGO:0051622 negative regulation of norepinephrine uptake IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 biological_processGO:0061024 membrane organization IMP
 biological_processGO:0070495 negative regulation of thrombin-activated receptor signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1903284 positive regulation of glutathione peroxidase activity IEA
 biological_processGO:1903285 positive regulation of hydrogen peroxide catabolic process IEA
 biological_processGO:1904715 negative regulation of chaperone-mediated autophagy IEA
 biological_processGO:1905606 regulation of presynapse assembly IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031092 platelet alpha granule membrane IEA
 cellular_componentGO:0043025 neuronal cell body IMP
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0099512 supramolecular fiber IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008198 ferrous iron binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA
 molecular_functionGO:0050544 arachidonic acid binding IDA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA
 molecular_functionGO:1903136 cuprous ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud,Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

Allelic Composition: Sncatm1.1Koks/Snca+
Genetic Background: either: B6.129P2-Sncatm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Abca12tm1Lex/Abca12tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud,Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aarssti/Aarstm1.1Slac
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd,Sncatm1Wtd/Sncatm1Wtd
Genetic Background: involves: 129 * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud,Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002717 abnormal preputial gland morphology "anomalous structure of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002822 catalepsy "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sncatm1.1Koks/Snca+
Genetic Background: either: B6.129P2-Sncatm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(Prnp-SNCA)7Vle/Tg(Prnp-SNCA)7Vle
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0003267 constipation "incomplete, infrequent or difficult evacuation of fecal matter " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sncatm1.1Koks/Snca+
Genetic Background: either: B6.129P2-Sncatm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(Prnp-SNCA)7Vle/Tg(Prnp-SNCA)7Vle
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA*A30P)192Rwm/0
Genetic Background: B6.Cg-Sncatm1Rosl Tg(SNCA*A30P)#Rwm

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca12tm1Lex/Abca12tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004191 neuronal intranuclear inclusions "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]
Show

Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Sncatm1Nbm/Sncatm1Nbm,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca12tm1Lex/Abca12tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd,Sncatm1Wtd/Sncatm1Wtd
Genetic Background: involves: 129 * C57BL/6

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sncatm1.1Koks/Snca+
Genetic Background: either: B6.129P2-Sncatm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA*A30P)192Rwm/0
Genetic Background: B6.Cg-Sncatm1Rosl Tg(SNCA*A30P)#Rwm

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

Allelic Composition: Sncatm1Nbm/Sncatm1Nbm,Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm,Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0006003 abnormal large intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the large intestine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

Allelic Composition: Sncatm1Nbm/Sncatm1Nbm,Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm,Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sncatm1Nbm/Sncatm1Nbm,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sncatm1Nbm/Sncatm1Nbm,Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm,Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca12tm1Lex/Abca12tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sncatm1.1Koks/Snca+
Genetic Background: either: B6.129P2-Sncatm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Tg(SNCA)OVX37Rwm/0
Genetic Background: B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl

 MP:0010540 long stride length "increased average distance between steps" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sncatm1.1Koks/Snca+
Genetic Background: either: B6.129P2-Sncatm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Abca12tm1Lex/Abca12tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
Show

Allelic Composition: Fmr1tm1Rbd/Y
Genetic Background: B6.129-Fmr1tm1Rbd

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Sncgtm1Vlb/Sncgtm1Vlb
Genetic Background: B6.129-Sncatm1Rosl Sncgtm1Vlb

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
Show

Allelic Composition: Abca12tm1Lex/Abca12tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl,Sncgtm1Vlb/Sncgtm1Vlb
Genetic Background: B6.129-Sncatm1Rosl Sncgtm1Vlb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr