ENSGALG00000011162


Gallus gallus

Features
Gene ID: ENSGALG00000011162
  
Biological name :CYP46A1
  
Synonyms : CYP46A1 / cytochrome P450 family 46 subfamily A member 1
  
Possible biological names infered from orthology : Cholesterol 24-hydroxylase / Q9WVK8 / Q9Y6A2
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 48244148
Gene end: 48259476
  
Corresponding Affymetrix probe sets: Gga.18483.1.S1_at (Chicken Array)   Gga.20024.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018174
NCBI entrez gene - 423450     See in Manteia.
RefSeq - NM_001252027
RefSeq - XM_015287469
RefSeq - XM_015287470
RefSeq Peptide - NP_001238956
swissprot - F1NEB6
Ensembl - ENSGALG00000011162
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp46a1.1ENSDARG00000093477Danio rerio
 cyp46a1.1ENSDARG00000012137Danio rerio
 cyp46a1.2ENSDARG00000004262Danio rerio
 cyp46a1.3ENSDARG00000089177Danio rerio
 cyp46a1.4ENSDARG00000113820Danio rerio
 Q9Y6A2ENSG00000036530Homo sapiens
 Q9WVK8ENSMUSG00000021259Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TBXAS1 / thromboxane A synthase 1 / P24557* / P36423* / thromboxane A synthase 1, platelet*ENSGALG0000001279124
CYP3A4 / Gallus gallus cytochrome P450 family 3 subfamily A member 4 (CYP3A4), mRNA.ENSGALG0000000443623
CYP3A5 / cytochrome P450 family 3 subfamily A member 5 / P20815* / P08684* / O09158* / Q9JMA7* / Q9HB55* / CYP3A4* / CYP3A7* / Q64464* / Q64481* / Q64459* / P24462* / Cyp3a11* / Cyp3a13* /...ENSGALG0000000444923
CYP24A1 / 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / Q07973* / Q64441* / cytochrome P450 family 24 subfamily A member 1*ENSGALG0000004227921
Q4G0S4* / CYP27C1* / cytochrome P450 family 27 subfamily C member 1*ENSGALG0000001153220
CYP11A1 / cholesterol side-chain cleavage enzyme, mitochondrial / P05108* / Q9QZ82* / cytochrome P450 family 11 subfamily A member 1*ENSGALG0000003498220
CYP27A1 / cytochrome P450 family 27 subfamily A member 1 / Q02318* / Q9DBG1* / Sterol 26-hydroxylase, mitochondrial *ENSGALG0000000247019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006707 cholesterol catabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0033781 cholesterol 24-hydroxylase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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