ENSGALG00000034982


Gallus gallus

Features
Gene ID: ENSGALG00000034982
  
Biological name :CYP11A1
  
Synonyms : cholesterol side-chain cleavage enzyme, mitochondrial / CYP11A1
  
Possible biological names infered from orthology : cytochrome P450 family 11 subfamily A member 1 / P05108 / Q9QZ82
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 2491141
Gene end: 2495357
  
Corresponding Affymetrix probe sets: Gga.591.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050999
NCBI entrez gene - 414838     See in Manteia.
RefSeq - NM_001001756
RefSeq Peptide - NP_001001756
swissprot - A0A1D5PE01
Ensembl - ENSGALG00000034982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp11a1ENSDARG00000002347Danio rerio
 cyp11a2ENSDARG00000092696Danio rerio
 P05108ENSG00000140459Homo sapiens
 Q9QZ82ENSMUSG00000032323Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP27A1 / cytochrome P450 family 27 subfamily A member 1 / Q02318* / Q9DBG1* / Sterol 26-hydroxylase, mitochondrial *ENSGALG0000000247029
Q4G0S4* / CYP27C1* / cytochrome P450 family 27 subfamily C member 1*ENSGALG0000001153226
CYP24A1 / 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / Q07973* / Q64441* / cytochrome P450 family 24 subfamily A member 1*ENSGALG0000004227926
CYP46A1 / cytochrome P450 family 46 subfamily A member 1 / Q9WVK8* / Q9Y6A2* / Cholesterol 24-hydroxylase *ENSGALG0000001116220
TBXAS1 / thromboxane A synthase 1 / P24557* / P36423* / thromboxane A synthase 1, platelet*ENSGALG0000001279120
CYP3A4 / Gallus gallus cytochrome P450 family 3 subfamily A member 4 (CYP3A4), mRNA.ENSGALG0000000443619
CYP3A5 / cytochrome P450 family 3 subfamily A member 5 / P20815* / P08684* / O09158* / Q9JMA7* / Q9HB55* / CYP3A4* / CYP3A7* / Q64464* / Q64481* / Q64459* / P24462* / Cyp3a11* / Cyp3a13* /...ENSGALG0000000444917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR033283  Cholesterol side-chain cleavage enzyme, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006700 C21-steroid hormone biosynthetic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008207 C21-steroid hormone metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000026507 FDX1 / ferredoxin 1 / P10109* / P46656*  / complex / reaction
 ENSGALG00000034982 CYP11A1 / cholesterol side-chain cleavage enzyme, mitochondrial / P05108* / Q9QZ82* / cytochrome P450 family 11 subfamily A member 1*  / reaction
 ENSGALG00000035816 FDXR / ferredoxin reductase / P22570* / Q61578*  / complex / reaction






 

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