ENSDARG00000002347


Danio rerio

Features
Gene ID: ENSDARG00000002347
  
Biological name :cyp11a1
  
Synonyms : cyp11a1 / cytochrome P450, family 11, subfamily A, polypeptide 1
  
Possible biological names infered from orthology : Cholesterol side-chain cleavage enzyme, mitochondrial / cytochrome P450 family 11 subfamily A member 1 / P05108 / Q9QZ82
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 22319940
Gene end: 22335283
  
Corresponding Affymetrix probe sets: Dr.6337.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000025030
Ensembl peptide - ENSDARP00000068056
Ensembl peptide - ENSDARP00000127507
Ensembl peptide - ENSDARP00000129033
Ensembl peptide - ENSDARP00000129542
NCBI entrez gene - 80374     See in Manteia.
RefSeq - NM_152953
RefSeq Peptide - NP_694485
swissprot - Q7SYJ6
swissprot - X1WBB6
swissprot - X1WFM9
swissprot - X1WH33
ZFIN ID - ZDB-GENE-010306-1
Ensembl - ENSDARG00000002347
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP11A1ENSGALG00000034982Gallus gallus
 P05108ENSG00000140459Homo sapiens
 Q9QZ82ENSMUSG00000032323Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cyp11a2 / cytochrome P450, family 11, subfamily A, polypeptide 2 / Q9QZ82* / P05108* / CYP11A1* / cytochrome P450 family 11 subfamily A member 1* / Cholesterol side-chain cleavage enzyme, m...ENSDARG0000009269681
cyp11c1 / cytochrome P450, family 11, subfamily C, polypeptide 1 / P19099* / P15538* / CYP11B1* / CYP11B2* / cytochrome P450 family 11 subfamily B member 2* / cytochrome P450 family 11 subf...ENSDARG0000004201439
cyp27a7 / cytochrome P450, family 27, subfamily A, polypeptide 7 / Q02318* / Q9DBG1* / CYP27A1* / Sterol 26-hydroxylase, mitochondrial * / cytochrome P450 family 27 subfamily A member 1*ENSDARG0000003380227
cyp27b1 / cytochrome P450, family 27, subfamily B, polypeptide 1 / O15528* / O35084* / cytochrome P450 family 27 subfamily B member 1* / 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial *ENSDARG0000004501527
si:dkey-91i10.3ENSDARG0000005726226
si:ch211-113j14.1ENSDARG0000007376426
A8WGA0 / cyp27c1 / cytochrome P450, family 27, subfamily C, polypeptide 1 / Q4G0S4* / cytochrome P450 family 27 subfamily C member 1*ENSDARG0000009266026
cyp24a1 / cytochrome P450, family 24, subfamily A, polypeptide 1 / Q07973* / Q64441* / cytochrome P450 family 24 subfamily A member 1* / 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial *ENSDARG0000010327726
cyp27a1.4 / cytochrome P450, family 27, subfamily A, polypeptide 1, gene 4 / Q02318* / Q9DBG1* / CYP27A1* / Sterol 26-hydroxylase, mitochondrial * / cytochrome P450 family 27 subfamily A member 1*ENSDARG0000005515925
cyp27a1.2 / cytochrome P450, family 27, subfamily A, polypeptide 1, gene 2 / Q02318* / Q9DBG1* / CYP27A1* / Sterol 26-hydroxylase, mitochondrial * / cytochrome P450 family 27 subfamily A member 1*ENSDARG0000006918625
zgc:136333 / CYP27A1 (1 of many) / Q02318* / Q9DBG1* / CYP27A1* / Sterol 26-hydroxylase, mitochondrial * / cytochrome P450 family 27 subfamily A member 1*ENSDARG0000008801325
cyp3c4 / cytochrome P450, family 3, subfamily C, polypeptide 4 / P20815* / P08684* / O09158* / P24462* / Q64459* / Q9JMA7* / CYP3A5* / Q9HB55* / CYP3A4* / CYP3A7* / Q64481* / Q64464* / Cyp3...ENSDARG0000007002118
cyp3a65 / cytochrome P450, family 3, subfamily A, polypeptide 65 / CYP3A4* / CYP3A5* / CYP3A7* / P08684* / P20815* / P24462* / Q9HB55* / CYP3A43* / CYP3A7-CYP3A51P* / CYP3A7-CYP3A51P readth...ENSDARG0000010329518
tbxas1 / thromboxane A synthase 1 (platelet) / P24557* / P36423* / thromboxane A synthase 1*ENSDARG0000000224917
cyp46a1.1 / cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1 / Q9Y6A2* / Q9WVK8* / CYP46A1* / Cholesterol 24-hydroxylase * / cytochrome P450 family 46 subfamily A member 1*ENSDARG0000001213717
cyp3c1 / cytochrome P450, family 3, subfamily c, polypeptide 1 / P20815* / P08684* / O09158* / P24462* / Q64459* / Q9JMA7* / CYP3A5* / Q9HB55* / CYP3A4* / CYP3A7* / Q64481* / Q64464* / Cyp3...ENSDARG0000001557517
cyp3c3 / cytochrome P450, family 3, subfamily c, polypeptide 3 / P20815* / P08684* / O09158* / P24462* / Q64459* / Q9JMA7* / CYP3A5* / Q9HB55* / CYP3A4* / CYP3A7* / Q64481* / Q64464* / Cyp3...ENSDARG0000003787317
cyp3c3 / cyp3c2 / cytochrome P450, family 3, subfamily c, polypeptide 2 / P08684* / O09158* / Q64459* / Q9JMA7* / CYP3A5* / Q9HB55* / CYP3A4* / CYP3A7* / Q64481* / Q64464* / P20815* / P2446...ENSDARG0000003787416
cyp46a1.3 / cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3 / Q9Y6A2* / CYP46A1* / cytochrome P450 family 46 subfamily A member 1*ENSDARG0000008917716
cyp46a1.1 / cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1 / Q9Y6A2* / CYP46A1* / cytochrome P450 family 46 subfamily A member 1*ENSDARG0000009347716


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002399  Cytochrome P450, mitochondrial
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR033283  Cholesterol side-chain cleavage enzyme, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006700 C21-steroid hormone biosynthetic process IMP
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008207 C21-steroid hormone metabolic process IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090504 epiboly IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis
Endogenous sterols


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk microtubule decreased thickness , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism dead , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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