ENSGALG00000011659


Gallus gallus
thiolaseactivityACAT2transferasegroupssitetransferringacylthiolase-likeactiveconservedn-terminalc-terminalfattyacidbeta-oxidationmetabolicprocessnucleusnucleoluscytoplasmmitochondrioncytosolcatalyticacetyl-coac-acetyltransferaseamino-acylcholesterolbiosynthesis

Features
Gene ID: ENSGALG00000011659
  
Biological name :ACAT2
  
Synonyms : ACAT2 / acetyl-CoA acetyltransferase 2
  
Possible biological names infered from orthology : Acat3 / acetyl-Coenzyme A acetyltransferase 2 / acetyl-Coenzyme A acetyltransferase 3 / Q8CAY6 / Q9BWD1
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 45735280
Gene end: 45743220
  
Corresponding Affymetrix probe sets: Gga.5262.2.S1_at (Chicken Array)   Gga.5262.3.S1_at (Chicken Array)   Gga.5262.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019037
NCBI entrez gene - 421587     See in Manteia.
RefSeq - NM_001039287
RefSeq Peptide - NP_001034376
swissprot - F1NT20
Ensembl - ENSGALG00000011659
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acat2ENSDARG00000007127Danio rerio
 ACAT2ENSG00000120437Homo sapiens
 Acat2ENSMUSG00000023832Mus musculus
 Acat3ENSMUSG00000062480Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACAT1 / acetyl-CoA acetyltransferase 1 / P24752* / Q8QZT1* / Acetyl-CoA acetyltransferase, mitochondrial *ENSGALG0000001716343
ACAA2 / 3-ketoacyl-CoA thiolase, mitochondrial / P42765* / Q8BWT1* / acetyl-CoA acyltransferase 2*ENSGALG0000003114243


Protein motifs (from Interpro)
Interpro ID Name
 IPR002155  Thiolase
 IPR016039  Thiolase-like
 IPR020610  Thiolase, active site
 IPR020613  Thiolase, conserved site
 IPR020616  Thiolase, N-terminal
 IPR020617  Thiolase, C-terminal


Gene Ontology (GO)
catabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processoxidation-reduction processcatabolic processcatabolic processcellular metabolic proccellular metabolic processprimary metabolic proceprimary metabolic processsmall molecule metabolismall molecule metabolic processorganic substance metaborganic substance metabolic processoxidation-reduction prooxidation-reduction process
transferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activitytransferase activity
cellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0006635 fatty acid beta-oxidation IBA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003985 acetyl-CoA C-acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011659 ACAT2 / acetyl-CoA acetyltransferase 2 / Acat3* / Q9BWD1* / Q8CAY6* / acetyl-Coenzyme A acetyltransferase 2* / acetyl-Coenzyme A acetyltransferase 3*  / complex






 

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