ENSGALG00000012704


Gallus gallus

Features
Gene ID: ENSGALG00000012704
  
Biological name :MYLIP
  
Synonyms : MYLIP / myosin regulatory light chain interacting protein
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase MYLIP / Q8BM54 / Q8WY64
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 61679759
Gene end: 61693984
  
Corresponding Affymetrix probe sets: Gga.16889.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020713
NCBI entrez gene - 420841     See in Manteia.
RefSeq - NM_001012561
RefSeq Peptide - NP_001012579
swissprot - Q5F429
Ensembl - ENSGALG00000012704
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mylipaENSDARG00000008859Danio rerio
 mylipbENSDARG00000055118Danio rerio
 MYLIPENSG00000007944Homo sapiens
 MylipENSMUSG00000038175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FARP1 / FERM, ARH/RhoGEF and pleckstrin domain protein 1 / F8VPU2* / Q9Y4F1* / FERM, ARHGEF and pleckstrin domain-containing protein 1 *ENSGALG0000001688626
FARP2 / FERM, ARH/RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *ENSGALG0000000578825
RDX / radixin / P26043* / P35241*ENSGALG0000001715323
MSN / moesin / P26038* / P26041*ENSGALG0000003961522
EZRENSGALG0000001374221
FRMD7 / FERM domain containing 7 / A2AD83* / Q6ZUT3* / FERM domain-containing protein 7 *ENSGALG0000002384321
NF2 / neurofibromin 2 / P35240* / P46662* / Merlin *ENSGALG0000000807320
ENSGALG000000023679


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001841  Zinc finger, RING-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032803 regulation of low-density lipoprotein particle receptor catabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
VLDLR internalisation and degradation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010166 VLDLR / P98165 / Very low-density lipoprotein receptor / P98155* / P98156*  / reaction
 ENSGALG00000012704 MYLIP / myosin regulatory light chain interacting protein / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP *  / complex






 

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