ENSGALG00000040424


Gallus gallus
sodiumSCNN1Achannelmembraneionepithelialtransporthomeostasisintegralcomponentplasmaactivitychordatesconservedsitetransmembranemulticellularorganismalwatercytoplasmapicalmotileciliumcomplexciliaryextracellularexosomeligand-gatedwwdomainbinding

Features
Gene ID: ENSGALG00000040424
  
Biological name :SCNN1A
  
Synonyms : amiloride-sensitive sodium channel subunit alpha / SCNN1A
  
Possible biological names infered from orthology : P37088 / sodium channel epithelial 1 alpha subunit / sodium channel, nonvoltage-gated 1 alpha
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 76898999
Gene end: 76910211
  
Corresponding Affymetrix probe sets: Gga.922.1.S1_a_at (Chicken Array)   Gga.922.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046969
Ensembl peptide - ENSGALP00000063913
NCBI entrez gene - 396050     See in Manteia.
RefSeq - XM_015293254
RefSeq - XM_015293236
RefSeq - XM_015293241
RefSeq - XM_015293249
RefSeq - NM_205145
RefSeq Peptide - NP_990476
swissprot - A0A1L1RYI8
swissprot - A0A1D5P2S0
Ensembl - ENSGALG00000040424
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P37088ENSG00000111319Homo sapiens
 Scnn1aENSMUSG00000030340Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SCNN1D / sodium channel epithelial 1 delta subunit / P51172*ENSGALG0000000183535
SCNN1G / sodium channel epithelial 1 gamma subunit / P51170* / Q9WU39* / Amiloride-sensitive sodium channel subunit gamma *ENSGALG0000000627032
SCNN1B / sodium channel epithelial 1 beta subunit / P51168* / Q9WU38* / sodium channel, nonvoltage-gated 1 beta*ENSGALG0000000620231
ASIC1 / Q1XA76 / Acid-sensing ion channel 1 / P78348* / Q6NXK8* / acid sensing ion channel subunit 1*ENSGALG0000003402519
ASIC4 / acid sensing ion channel subunit family member 4 / Q7TNS7* / Q96FT7* / Acid-sensing ion channel 4 *ENSGALG0000001125018
ASIC2 / acid sensing ion channel subunit 2 / Q16515* / Q925H0* / Acid-sensing ion channel 2 *ENSGALG0000000036717
ASIC5 / acid sensing ion channel subunit family member 5 / Q9NY37* / Q9R0Y1* / Acid-sensing ion channel 5 *ENSGALG000000093668
ENSGALG000000198246


Protein motifs (from Interpro)
Interpro ID Name
 IPR001873  Epithelial sodium channel
 IPR004724  Epithelial sodium channel, chordates
 IPR020903  Epithelial sodium channel, conserved site


Gene Ontology (GO)
establishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationregulation of biological qualityestablishment of localizationestablishment of localizationregulation of biological qualityregulation of biological quality
transmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activitytransmembrane transporter activityprotein bindingprotein binding
cellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellmembraneorganelleprotein-containing complexextracellular regioncellcellmembranemembraneorganelleorganelleprotein-containing complexprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0050891 multicellular organismal water homeostasis IEA
 biological_processGO:0055078 sodium ion homeostasis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0034706 sodium channel complex IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0015280 ligand-gated sodium channel activity IEA
 molecular_functionGO:0050699 WW domain binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000006270 SCNN1G / sodium channel epithelial 1 gamma subunit / P51170* / Q9WU39* / Amiloride-sensitive sodium channel subunit gamma *  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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