ENSGALG00000046159


Gallus gallus
regulationKNG1cystatinextracellulardomaininhibitorendopeptidaseactivitybindinginsulin-likegrowthfactorgalphasignallingeventsproteinaseconservedsitekininogen-typecelladhesioncytosoliccalciumionconcentrationbloodcoagulationproteolysisregionspace

Features
Gene ID: ENSGALG00000046159
  
Biological name :KNG1
  
Synonyms : kininogen 1 / KNG1
  
Possible biological names infered from orthology : Kininogen-1 Kininogen-1 heavy chain Bradykinin Kininogen-1 light chain / kininogen 2 / Kng2 / O08677 / P01042
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 16218893
Gene end: 16235485
  
Corresponding Affymetrix probe sets: GgaAffx.5462.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060409
NCBI entrez gene - 424957     See in Manteia.
RefSeq - XM_422766
swissprot - A0A1L1RNR4
Ensembl - ENSGALG00000046159
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kng1ENSDARG00000022372Danio rerio
 KNG1ENSG00000113889Homo sapiens
 Kng1ENSMUSG00000022875Mus musculus
 Kng2ENSMUSG00000060459Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR018073  Proteinase inhibitor I25, cystatin, conserved site
 IPR027358  Kininogen-type cystatin domain


Gene Ontology (GO)
cell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesionregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationcell adhesioncell adhesionregulation of regulation of biological qualitynitrogen componitrogen compound metabolic processcellular metabcellular metabolic processprimary metaboprimary metabolic processregulation of regulation of molecular functionorganic substaorganic substance metabolic processresponse to stresponse to stressresponse to exresponse to external stimuluscoagulationcoagulation
enzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityenzyme regulator activityprotein bindingprotein binding
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030195 negative regulation of blood coagulation IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
G alpha (i) signalling events
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr