ENSMUSG00000060459


Mus musculus
regulationKng2activitycystatininhibitorextracellulardomainpeptidaseendopeptidasebloodbindinginsulin-likegrowthfactorgalphasignallingeventsincreasedbodyhmwkininogenproteinaseconservedsitekininogen-typecytosoliccalciumionconcentrationcoagulation

Features
Gene ID: ENSMUSG00000060459
  
Biological name :Kng2
  
Synonyms : kininogen 2 / Kng2
  
Possible biological names infered from orthology : kininogen 1 / KNG1 / P01042
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 22985854
Gene end: 23029101
  
Corresponding Affymetrix probe sets: 10438681 (MoGene1.0st)   1416676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046867
Ensembl peptide - ENSMUSP00000097623
Ensembl peptide - ENSMUSP00000111006
Ensembl peptide - ENSMUSP00000124161
NCBI entrez gene - 385643     See in Manteia.
MGI - MGI:3027157
RefSeq - XM_006522324
RefSeq - NM_001102409
RefSeq - NM_001102410
RefSeq - NM_201375
RefSeq Peptide - NP_001095879
RefSeq Peptide - NP_001095880
RefSeq Peptide - NP_958763
swissprot - Q6S9I0
swissprot - Q6S9I2
swissprot - Q6S9I3
swissprot - E0CYI5
Ensembl - ENSMUSG00000060459
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kng1ENSDARG00000022372Danio rerio
 KNG1ENSGALG00000046159Gallus gallus
 KNG1ENSG00000113889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kng1 / O08677 / Kininogen-1 Kininogen-1 heavy chain Bradykinin Kininogen-1 light chain / P01042* / kininogen 1*ENSMUSG0000002287584


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR002395  HMW kininogen
 IPR018073  Proteinase inhibitor I25, cystatin, conserved site
 IPR027358  Kininogen-type cystatin domain


Gene Ontology (GO)
regulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processresponse to stressresponse to external stimuluscoagulationregulation of bregulation of biological qualitynitrogen compounitrogen compound metabolic processcellular metabocellular metabolic processprimary metabolprimary metabolic processregulation of mregulation of molecular functionorganic substanorganic substance metabolic processresponse to strresponse to stressresponse to extresponse to external stimuluscoagulationcoagulation
enzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityenzyme regulator activityprotein bindingprotein binding
extracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regionextracellular regioncellcell
TypeGO IDTermEv.Code
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030195 negative regulation of blood coagulation IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
G alpha (i) signalling events
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
growth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotypegrowth/size phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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