ENSMUSG00000022875


Mus musculus

Features
Gene ID: ENSMUSG00000022875
  
Biological name :Kng1
  
Synonyms : Kininogen-1 Kininogen-1 heavy chain Bradykinin Kininogen-1 light chain / Kng1 / O08677
  
Possible biological names infered from orthology : kininogen 1 / P01042
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B1
Gene start: 23057865
Gene end: 23082068
  
Corresponding Affymetrix probe sets: 10434719 (MoGene1.0st)   1416676_at (Mouse Genome 430 2.0 Array)   1426045_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087346
Ensembl peptide - ENSMUSP00000121701
Ensembl peptide - ENSMUSP00000023589
Ensembl peptide - ENSMUSP00000040485
NCBI entrez gene - 16644     See in Manteia.
MGI - MGI:1097705
RefSeq - XM_006521813
RefSeq - NM_001102411
RefSeq - NM_001102412
RefSeq - NM_023125
RefSeq - XM_006521812
RefSeq Peptide - NP_001095882
RefSeq Peptide - NP_075614
RefSeq Peptide - NP_001095881
swissprot - O08677
swissprot - D3Z2B2
swissprot - A0A0R4J038
swissprot - D3YTY9
Ensembl - ENSMUSG00000022875
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kng1ENSDARG00000022372Danio rerio
 KNG1ENSGALG00000046159Gallus gallus
 KNG1ENSG00000113889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kng2 / kininogen 2 / KNG1* / P01042* / kininogen 1*ENSMUSG0000006045982


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR002395  HMW kininogen
 IPR018073  Proteinase inhibitor I25, cystatin, conserved site
 IPR027358  Kininogen-type cystatin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030195 negative regulation of blood coagulation IBA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
G alpha (i) signalling events
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr