Manteia

ENSMUSG00000001566

Mus musculus

Features

Gene ID:	ENSMUSG00000001566

Biological name :	Mnx1

Synonyms :	Mnx1 / motor neuron and pancreas homeobox 1 / Q9QZW9

Possible biological names infered from orthology :	P50219

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	B1
Gene start:	29473034
Gene end:	29478470

Corresponding Affymetrix probe sets:	10528903 (MoGene1.0st) 1460299_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000129503 Ensembl peptide - ENSMUSP00000001608 NCBI entrez gene - 15285 See in Manteia. MGI - MGI:109160 RefSeq - NM_019944 RefSeq Peptide - NP_064328 swissprot - A2RSX2 swissprot - Q9QZW9 Ensembl - ENSMUSG00000001566

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mnx1	ENSDARG00000035984	Danio rerio
MNX1	ENSGALG00000041154	Gallus gallus
MNX1	ENSG00000130675	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gbx1 / P82976 / Homeobox protein GBX-1 / Q14549* / gastrulation brain homeobox 1*	ENSMUSG00000067724	21
Evx1 / P23683 / Homeobox even-skipped homolog protein 1 / P49640* / even-skipped homeobox 1*	ENSMUSG00000005503	20
Nkx1-1 / NK1 transcription factor-related protein 1 / Q15270* / NK1 homeobox 1*	ENSMUSG00000029112	20
Evx2 / P49749 / Homeobox even-skipped homolog protein 2 / Q03828* / even-skipped homeobox 2*	ENSMUSG00000001815	18
Gbx2 / P48031 / Homeobox protein GBX-2 / P52951* / gastrulation brain homeobox 2*	ENSMUSG00000034486	18
Nkx1-2 / P42580 / NK1 transcription factor-related protein 2 / Q9UD57* / NK1 homeobox 2*	ENSMUSG00000048528	17
Meox1 / P32442 / Homeobox protein MOX-1 / P50221* / mesenchyme homeobox 1*	ENSMUSG00000001493	14
Meox2 / P32443 / Homeobox protein MOX-2 / P50222* / mesenchyme homeobox 2*	ENSMUSG00000036144	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site
IPR020479	Homeobox domain, metazoa

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001764	neuron migration	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IBA
biological_process	GO:0008045	motor neuron axon guidance	IMP
biological_process	GO:0009791	post-embryonic development	IMP
biological_process	GO:0021520	spinal cord motor neuron cell fate specification	IMP
biological_process	GO:0021675	nerve development	IMP
biological_process	GO:0021904	dorsal/ventral neural tube patterning	IDA
biological_process	GO:0021953	central nervous system neuron differentiation	IMP
biological_process	GO:0030182	neuron differentiation	IMP
biological_process	GO:0031016	pancreas development	IMP
biological_process	GO:0031018	endocrine pancreas development	IMP
biological_process	GO:0048667	cell morphogenesis involved in neuron differentiation	IMP
biological_process	GO:0048812	neuron projection morphogenesis	IMP
biological_process	GO:0060539	diaphragm development	IMP
biological_process	GO:0060541	respiratory system development	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005730	nucleolus	ISO
cellular_component	GO:0005829	cytosol	ISO
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IBA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0000747	muscle weakness	"loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0000761	thin diaphragm muscle	"reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]	Show Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm2Tmj/Mnx1^tm2Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm3Tmj/Mnx1^tm3Tmj Genetic Background: involves: 129S1/Sv
MP:0000937	abnormal motor neuron morphology	"malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Isl2^tm1Arbr/Isl2⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Mnx1^tm1Jhk/Mnx1^tm1Jhk,Isl2^tm2Slp/Isl2^tm2Slp Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm2Tmj/Mnx1^tm2Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm3Tmj/Mnx1^tm3Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Lrp4^tm1.1Line/Lrp4^tm1.1Line,Mnx1^tm4(cre)Tmj/Mnx1⁺,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0000938	motor neuron degeneration	"retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0000939	reduced motor neuron number	"fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Ret^tm2(RET)Heno/Ret^tm2(RET)Heno Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Gfra1^tm2Jmi/Gfra1^tm2Jmi,Mnx1^tm4(cre)Tmj/Mnx1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0000940	abnormal motor neuron innervation	"misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Mnx1^tm1Jhk/Mnx1^tm1Jhk,Isl2^tm2Slp/Isl2^tm2Slp Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Ret^tm2(RET)Heno/Ret^tm2(RET)Heno Genetic Background: involves: C57BL/6 * SJL
MP:0001053	abnormal neuromuscular synapse	"malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Mycbp2^tm1Adia/Mycbp2^tm1Adia Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Lrp4^tm1.1Line/Lrp4^tm1.1Line,Mnx1^tm4(cre)Tmj/Mnx1⁺,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺ Genetic Background: involves: 129S1/Sv
MP:0001076	abnormal hypoglossal nerve morphology	"malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Mnx1^tm2Tmj/Mnx1^tm2Tmj Genetic Background: involves: 129S1/Sv
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Smn1^tm1Cdid/Smn1^tm1.1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * C57BL/6 * FVB Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh23^m1Btlr/Cdh23^m1Btlr Genetic Background: C57BL/6J-Cdh23^m1Btlr
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Smn1^tm1Cdid/Smn1^tm1.1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * C57BL/6 * FVB
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Lrp4^tm1.1Line/Lrp4^tm1.1Line,Mnx1^tm4(cre)Tmj/Mnx1⁺,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL
MP:0001636	irregular heartbeat	"uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh23^m1Btlr/Cdh23^m1Btlr Genetic Background: C57BL/6J-Cdh23^m1Btlr
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aplp2^tm1Dbo/Aplp2^tm1Dbo,App^tm1.2Zhe/App^tm1.2Zhe Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Rhot1^tm1.1Jmsu/Rhot1^tm1.2Jmsu Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL
MP:0002184	abnormal innervation	"the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Adgrv1^tm1Pwh/Adgrv1^tm1Pwh Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0002269	muscular atrophy	"a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0002578	impaired ability to fire action potentials	"anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ildr1^{tm1(KOMP)Wtsi}/Ildr1^{tm1(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002651	abnormal sciatic nerve	"malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ildr1^{tm1(KOMP)Wtsi}/Ildr1^{tm1(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002862	altered righting response	"altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0002946	delayed axon outgrowth	"an increased amount of time required for an axon to extend from a neuron cell body and find the target" [J:77048, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ildr1^{tm1(KOMP)Wtsi}/Ildr1^{tm1(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002961	abnormal axon guidance	"defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Adgrv1^tm1Pwh/Adgrv1^tm1Pwh Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Mnx1^tm1Jhk/Mnx1^tm1Jhk,Isl2^tm2Slp/Isl2^tm2Slp Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
MP:0003233	prolonged QT interval	"increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0003271	abnormal duodenum morphology	"malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv
MP:0003339	decreased number of pancreatic beta cells	"fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pax6^10Neu/Pax6^10Neu Genetic Background: involves: 102 * C3H Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0003562	abnormal beta cell physiology	"anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pax6^10Neu/Pax6^10Neu Genetic Background: involves: 102 * C3H
MP:0003651	abnormal axon outgrowth	"defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]	Show Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MP:0003896	prolonged PQ interval	"increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0003934	abnormal pancreas development	"anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pax6^10Neu/Pax6^10Neu Genetic Background: involves: 102 * C3H Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^10Neu/Pax6^10Neu Genetic Background: involves: 102 * C3H
MP:0004220	abnormal peripheral nervous system regeneration	"changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ildr1^{tm1(KOMP)Wtsi}/Ildr1^{tm1(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0005112	abnormal anterior horn morphology	"anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pax6^10Neu/Pax6^10Neu Genetic Background: involves: 102 * C3H Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv
MP:0005218	abnormal pancreatic delta cell morphology	"malformation of the cells found in the pancreas and gastrointestinal tract that secrete somatostatin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pax6^10Neu/Pax6^10Neu Genetic Background: involves: 102 * C3H
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm2Tmj/Mnx1^tm2Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm3Tmj/Mnx1^tm3Tmj Genetic Background: involves: 129S1/Sv
MP:0008143	abnormal dendrite morphology	"any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dstn^corn1/Dstn^corn1,Cxcr2^tm1Mwm/Cxcr2^tm1Mwm Genetic Background: involves: 129S2/SvPas * A/WySn * BALB/c * brachy stock
MP:0008814	reduced nerve conduction velocity	"decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ildr1^{tm1(KOMP)Wtsi}/Ildr1^{tm1(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0009172	small pancreatic islets	"decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Pax6^10Neu/Pax6^10Neu Genetic Background: involves: 102 * C3H
MP:0009181	decreased pancreatic delta cell number	"reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]	Show Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv
MP:0009400	decreased skeletal muscle fiber size	"decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺ Genetic Background: involves: 129S1/Sv
MP:0010819	primary atelectasis	"nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm2Tmj/Mnx1^tm2Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm3Tmj/Mnx1^tm3Tmj Genetic Background: involves: 129S1/Sv
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Smn1^tm1Cdid/Smn1^tm1Cdid,Grm7^{Tg(SMN2)89Ahmb}/Grm7⁺ Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Pax6^10Neu/Pax6^10Neu Genetic Background: involves: 102 * C3H Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm2Tmj/Mnx1^tm2Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Mnx1^tm3Tmj/Mnx1^tm3Tmj Genetic Background: involves: 129S1/Sv Allelic Composition: Lrp4^tm1.1Line/Lrp4^tm1.1Line,Mnx1^tm4(cre)Tmj/Mnx1⁺,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Mycbp2^tm1Adia/Mycbp2^tm1Adia Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0020448	increased microglial cell activation	"increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]	Show Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺,Tardbp^tm1.1Ckjs/Tardbp^tm1.2Cjks Genetic Background: involves: 129S1/Sv * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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