ENSMUSG00000029112


Mus musculus

Features
Gene ID: ENSMUSG00000029112
  
Biological name :Nkx1-1
  
Synonyms : NK1 transcription factor-related protein 1 / Nkx1-1
  
Possible biological names infered from orthology : NK1 homeobox 1 / Q15270
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 33430734
Gene end: 33433976
  
Corresponding Affymetrix probe sets: 10529285 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000133620
NCBI entrez gene - 672284     See in Manteia.
MGI - MGI:109346
RefSeq - NM_011320
RefSeq Peptide - NP_035450
swissprot - G3UXB3
Ensembl - ENSMUSG00000029112
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx1.2lbENSDARG00000099427Danio rerio
 NKX1-1ENSGALG00000035650Gallus gallus
 NKX1-1ENSG00000235608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkx1-2 / P42580 / NK1 transcription factor-related protein 2 / Q9UD57* / NK1 homeobox 2*ENSMUSG0000004852835
Mnx1 / Q9QZW9 / motor neuron and pancreas homeobox 1 / P50219*ENSMUSG0000000156620
Evx1 / P23683 / Homeobox even-skipped homolog protein 1 / P49640* / even-skipped homeobox 1*ENSMUSG0000000550320
Gbx2 / P48031 / Homeobox protein GBX-2 / P52951* / gastrulation brain homeobox 2*ENSMUSG0000003448618
Gbx1 / P82976 / Homeobox protein GBX-1 / Q14549* / gastrulation brain homeobox 1*ENSMUSG0000006772418
Meox1 / P32442 / Homeobox protein MOX-1 / P50221* / mesenchyme homeobox 1*ENSMUSG0000000149315
Evx2 / P49749 / Homeobox even-skipped homolog protein 2 / Q03828* / even-skipped homeobox 2*ENSMUSG0000000181515
Meox2 / P32443 / Homeobox protein MOX-2 / P50222* / mesenchyme homeobox 2*ENSMUSG0000003614412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0043467 regulation of generation of precursor metabolites and energy IMP
 biological_processGO:0050877 nervous system process IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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