ENSMUSG00000003420


Mus musculus

Features
Gene ID: ENSMUSG00000003420
  
Biological name :Fcgrt
  
Synonyms : Fcgrt / Mus musculus Fc receptor, IgG, alpha chain transporter (Fcgrt), transcript variant 2, mRNA. / Q61559
  
Possible biological names infered from orthology : Fc fragment of IgG receptor and transporter / P55899
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45092990
Gene end: 45103851
  
Corresponding Affymetrix probe sets: 10563085 (MoGene1.0st)   1416978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147757
Ensembl peptide - ENSMUSP00000147969
Ensembl peptide - ENSMUSP00000003512
Ensembl peptide - ENSMUSP00000147496
NCBI entrez gene - 14132     See in Manteia.
MGI - MGI:103017
RefSeq - NM_010189
RefSeq - XM_006540603
RefSeq - NM_001357117
RefSeq Peptide - NP_001344046
RefSeq Peptide - NP_034319
swissprot - A0A1B0GS17
swissprot - Q61559
swissprot - Q6PKB0
swissprot - A0A1B0GSK0
Ensembl - ENSMUSG00000003420
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR339041.1ENSDARG00000051710Danio rerio
 CR339041.2ENSDARG00000051711Danio rerio
 CR339041.3ENSDARG00000115781Danio rerio
 FO904903.1ENSDARG00000059039Danio rerio
 mhc1laaENSDARG00000016056Danio rerio
 mhc1lbaENSDARG00000016227Danio rerio
 mhc1ldaENSDARG00000023203Danio rerio
 mhc1lfaENSDARG00000051712Danio rerio
 mhc1lgaENSDARG00000051713Danio rerio
 mhc1liaENSDARG00000097766Danio rerio
 mhc1ljaENSDARG00000096830Danio rerio
 mhc1llaENSDARG00000096977Danio rerio
 mhc1ubaENSDARG00000075963Danio rerio
 mhc1ukaENSDARG00000092731Danio rerio
 mhc1umaENSDARG00000039164Danio rerio
 si:ch211-147g22.4ENSDARG00000097275Danio rerio
 si:dkey-225f5.5ENSDARG00000055813Danio rerio
 si:dkey-52p2.5ENSDARG00000096940Danio rerio
 FCGRTENSG00000104870Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hfe / P70387 / Hereditary hemochromatosis protein homolog / Q30201* / hemochromatosis*ENSMUSG0000000661126
Mr1 / Q8HWB0 / major histocompatibility complex, class I-related / Q95460*ENSMUSG0000002647124
Azgp1 / Q64726 / Zinc-alpha-2-glycoprotein / P25311* / alpha-2-glycoprotein 1, zinc-binding*ENSMUSG0000003705324
H2-T22 / histocompatibility 2, T region locus 22ENSMUSG0000005611623
H2-T10 / histocompatibility 2, T region locus 10ENSMUSG0000007949123
H2-M10.2 / histocompatibility 2, M region locus 10.2ENSMUSG0000002308322
H2-M10.1ENSMUSG0000002444822
H2-M10.6 / histocompatibility 2, M region locus 10.6ENSMUSG0000003713022
H2-M10.3ENSMUSG0000005812422
H2-M10.5ENSMUSG0000003724621
H2-M10.4ENSMUSG0000004823121
H2-T24ENSMUSG0000005383521
Mill2 / MHC I like leukocyte 2 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*ENSMUSG0000004098720
Mill1 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*ENSMUSG0000005400520
2410137M14Rik / RIKEN cDNA 2410137M14 geneENSMUSG000000643089


Protein motifs (from Interpro)
Interpro ID Name
 IPR001039  MHC class I alpha chain, alpha1 alpha2 domains
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0038094 Fc-gamma receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0019770 IgG receptor activity IBA
 molecular_functionGO:0019864 IgG binding ISO
 molecular_functionGO:0030881 beta-2-microglobulin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Fcgrttm1Dcr/Fcgrttm1Dcr
Genetic Background: B6.129X1-Fcgrttm1Dcr/DcrJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

Allelic Composition: Fcgrttm1Dcr/Fcgrttm1Dcr
Genetic Background: B6.129X1-Fcgrttm1Dcr/DcrJ

Allelic Composition: Albem12Mvw/Albem12Mvw,Fcgrttm1Dcr/Fcgrttm1Dcr,Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr
Genetic Background: B6.Cg-Albem12Mvw Fcgrttm1Dcr Tg(FCGRT)32Dcr/MvwJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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