ENSMUSG00000026471


Mus musculus

Features
Gene ID: ENSMUSG00000026471
  
Biological name :Mr1
  
Synonyms : major histocompatibility complex, class I-related / Mr1 / Q8HWB0
  
Possible biological names infered from orthology : Q95460
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 155127277
Gene end: 155146814
  
Corresponding Affymetrix probe sets: 10358982 (MoGene1.0st)   1421898_a_at (Mouse Genome 430 2.0 Array)   1421899_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141476
Ensembl peptide - ENSMUSP00000142195
Ensembl peptide - ENSMUSP00000027744
NCBI entrez gene - 15064     See in Manteia.
MGI - MGI:1195463
RefSeq - XM_006529143
RefSeq - XM_006529144
RefSeq - NM_008209
RefSeq Peptide - NP_032235
swissprot - Q8HWB0
swissprot - A0A0A6YXY6
swissprot - A0A0A6YWB2
Ensembl - ENSMUSG00000026471
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR339041.1ENSDARG00000051710Danio rerio
 CR339041.2ENSDARG00000051711Danio rerio
 CR339041.3ENSDARG00000115781Danio rerio
 FO904903.1ENSDARG00000059039Danio rerio
 mhc1laaENSDARG00000016056Danio rerio
 mhc1lbaENSDARG00000016227Danio rerio
 mhc1ldaENSDARG00000023203Danio rerio
 mhc1lfaENSDARG00000051712Danio rerio
 mhc1lgaENSDARG00000051713Danio rerio
 mhc1liaENSDARG00000097766Danio rerio
 mhc1ljaENSDARG00000096830Danio rerio
 mhc1llaENSDARG00000096977Danio rerio
 mhc1ubaENSDARG00000075963Danio rerio
 mhc1ukaENSDARG00000092731Danio rerio
 mhc1umaENSDARG00000039164Danio rerio
 si:ch211-147g22.4ENSDARG00000097275Danio rerio
 si:dkey-225f5.5ENSDARG00000055813Danio rerio
 si:dkey-52p2.5ENSDARG00000096940Danio rerio
 ENSGALG00000026466Gallus gallus
 ENSGALG00000043619Gallus gallus
 ENSGALG00000035251Gallus gallus
 ENSGALG00000032602Gallus gallus
 ENSGALG00000030320Gallus gallus
 ENSGALG00000040901Gallus gallus
 BF1ENSGALG00000033932Gallus gallus
 BF2ENSGALG00000041380Gallus gallus
 MR1ENSG00000153029Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hfe / P70387 / Hereditary hemochromatosis protein homolog / Q30201* / hemochromatosis*ENSMUSG0000000661131
H2-T24ENSMUSG0000005383530
H2-M10.1ENSMUSG0000002444829
H2-T22 / histocompatibility 2, T region locus 22ENSMUSG0000005611629
H2-M10.2 / histocompatibility 2, M region locus 10.2ENSMUSG0000002308328
Azgp1 / Q64726 / Zinc-alpha-2-glycoprotein / P25311* / alpha-2-glycoprotein 1, zinc-binding*ENSMUSG0000003705328
H2-M10.6 / histocompatibility 2, M region locus 10.6ENSMUSG0000003713028
H2-M10.3ENSMUSG0000005812428
H2-T10 / histocompatibility 2, T region locus 10ENSMUSG0000007949128
Mill2 / MHC I like leukocyte 2 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*ENSMUSG0000004098727
H2-M10.4ENSMUSG0000004823127
Fcgrt / Q61559 / Mus musculus Fc receptor, IgG, alpha chain transporter (Fcgrt), transcript variant 2, mRNA. / P55899* / Fc fragment of IgG receptor and transporter*ENSMUSG0000000342026
H2-M10.5ENSMUSG0000003724626
Mill1 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*ENSMUSG0000005400526
2410137M14Rik / RIKEN cDNA 2410137M14 geneENSMUSG000000643089


Protein motifs (from Interpro)
Interpro ID Name
 IPR001039  MHC class I alpha chain, alpha1 alpha2 domains
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002367 cytokine production involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA
 biological_processGO:0032611 interleukin-1 beta production IMP
 biological_processGO:0032620 interleukin-17 production IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042612 MHC class I protein complex IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stk11tm1.1Rdp/Stk11+,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Rdp/Stk11+,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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